2-(4-{[(7-cyanoquinolin-4-yl)amino]methyl}-1H-1,2,3-triazol-1-yl)-N,N-dicyclohexylacetamide

Base Information

Chemical Name:2-(4-{[(7-cyanoquinolin-4-yl)amino]methyl}-1H-1,2,3-triazol-1-yl)-N,N-dicyclohexylacetamide
CAS No.:1491137-40-6
Molecular Formula:C₂₇H₃₃N₇O
Molecular Weight:471.605
Hs Code.:

Synonyms:2-(4-{[(7-cyanoquinolin-4-yl)amino]methyl}-1H-1,2,3-triazol-1-yl)-N,N-dicyclohexylacetamide

Suppliers and Price of 2-(4-{[(7-cyanoquinolin-4-yl)amino]methyl}-1H-1,2,3-triazol-1-yl)-N,N-dicyclohexylacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(4-{[(7-cyanoquinolin-4-yl)amino]methyl}-1H-1,2,3-triazol-1-yl)-N,N-dicyclohexylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(4-{[(7-cyanoquinolin-4-yl)amino]methyl}-1H-1,2,3-triazol-1-yl)-N,N-dicyclohexylacetamide

There total 6 articles about 2-(4-{[(7-cyanoquinolin-4-yl)amino]methyl}-1H-1,2,3-triazol-1-yl)-N,N-dicyclohexylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2567-50-2
N,N-bis-(cyclohexyl)chloroacetamide

: 1491137-40-6
2-(4-{[(7-cyanoquinolin-4-yl)amino]methyl}-1H-1,2,3-triazol-1-yl)-N,N-dicyclohexylacetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium azide / N,N-dimethyl-formamide / 20 °C

2.1: sodium L-ascorbate; copper(ll) sulfate pentahydrate / tert-butyl alcohol; water / 60 - 80 °C

3.1: trifluoroacetic acid / dichloromethane; methanol / 0 - 20 °C

4.1: hydrogenchloride / methanol; 1,4-dioxane / 0 °C

5.1: triethylamine / ethanol / 0 °C / Inert atmosphere

5.2: 8 h / 130 - 135 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate; triethylamine; trifluoroacetic acid; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.ejmech.2013.08.046

Reference yield:

: 181950-55-0
4-chloroquinoline-7-carbonitrile

: C₁₇H₂₉N₅O*ClH

: 1491137-40-6
2-(4-{[(7-cyanoquinolin-4-yl)amino]methyl}-1H-1,2,3-triazol-1-yl)-N,N-dicyclohexylacetamide

Guidance literature:: C₁₇H₂₉N₅O*ClH; With triethylamine; In ethanol; at 0 ℃; Inert atmosphere;

4-chloroquinoline-7-carbonitrile; In ethanol; at 130 - 135 ℃; for 8h; Inert atmosphere; Sealed tube;
DOI:10.1016/j.ejmech.2013.08.046

Reference yield:

: 1093981-69-1
2-azido-N,N-dicyclohexylacetamide

: 1491137-40-6
2-(4-{[(7-cyanoquinolin-4-yl)amino]methyl}-1H-1,2,3-triazol-1-yl)-N,N-dicyclohexylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium L-ascorbate; copper(ll) sulfate pentahydrate / tert-butyl alcohol; water / 60 - 80 °C

2.1: trifluoroacetic acid / dichloromethane; methanol / 0 - 20 °C

3.1: hydrogenchloride / methanol; 1,4-dioxane / 0 °C

4.1: triethylamine / ethanol / 0 °C / Inert atmosphere

4.2: 8 h / 130 - 135 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; copper(ll) sulfate pentahydrate; sodium L-ascorbate; triethylamine; trifluoroacetic acid; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/j.ejmech.2013.08.046