O-(5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl) O-(tert-butyl) thiophosphorofluoridate

Base Information

Chemical Name:O-(5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl) O-(tert-butyl) thiophosphorofluoridate
CAS No.:171081-18-8
Molecular Formula:C₃₅H₄₀FN₂O₈PS
Molecular Weight:698.749
Hs Code.:

Synonyms:O-(5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl) O-(tert-butyl) thiophosphorofluoridate

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Chemical Property of O-(5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl) O-(tert-butyl) thiophosphorofluoridate

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Technology Process of O-(5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl) O-(tert-butyl) thiophosphorofluoridate

There total 6 articles about O-(5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl) O-(tert-butyl) thiophosphorofluoridate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 171081-10-0
O-(5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl) O-(tert-butyl) phosphorofluoridite

: 171081-18-8
O-(5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl) O-(tert-butyl) thiophosphorofluoridate

Guidance literature:: With (C₃H₇)2NH; sulfur; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1039/b103082p DOI:10.1039/b413552k

Reference yield:

: 162611-40-7,162611-41-8,171081-08-6
5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl-(N,N-diisopropylamino)phosphorofluoridite

: 171081-18-8
O-(5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl) O-(tert-butyl) thiophosphorofluoridate

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / Me₃SiCl / tetrahydrofuran / 1 h

2: 97 percent / sulfur; (C₃H₇)2NH / tetrahydrofuran / 2 h / 20 °C

With chloro-trimethyl-silane; (C₃H₇)2NH; sulfur; In tetrahydrofuran;
DOI:10.1039/b413552k

Reference yield:

: 153413-66-2,162681-43-8,162681-44-9
O-(5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl) O-(4-nitrophenyl) N,N-diisopropylphosphoramidite

: 171081-18-8
O-(5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl) O-(tert-butyl) thiophosphorofluoridate

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / TBAF / tetrahydrofuran / 0.17 h / 20 °C

2: 90 percent / Me₃SiCl / tetrahydrofuran / 1 h

3: 97 percent / sulfur; (C₃H₇)2NH / tetrahydrofuran / 2 h / 20 °C

With chloro-trimethyl-silane; (C₃H₇)2NH; tetrabutyl ammonium fluoride; sulfur; In tetrahydrofuran;
DOI:10.1039/b413552k