(+/-)-methyl 2-[[(2-amino-5-chlorophenyl)methyl]amino]-3-methylbutanoate

Base Information

Chemical Name:(+/-)-methyl 2-[[(2-amino-5-chlorophenyl)methyl]amino]-3-methylbutanoate
CAS No.:258850-20-3
Molecular Formula:C₁₃H₁₉ClN₂O₂
Molecular Weight:270.759
Hs Code.:

Synonyms:(+/-)-methyl 2-[[(2-amino-5-chlorophenyl)methyl]amino]-3-methylbutanoate

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Chemical Property of (+/-)-methyl 2-[[(2-amino-5-chlorophenyl)methyl]amino]-3-methylbutanoate

Chemical Property:

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Technology Process of (+/-)-methyl 2-[[(2-amino-5-chlorophenyl)methyl]amino]-3-methylbutanoate

There total 4 articles about (+/-)-methyl 2-[[(2-amino-5-chlorophenyl)methyl]amino]-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 258850-15-6
(+/-)-methyl 2-[[(5-chloro-2-nitrophenyl)methyl]amino]-3-methylbutanoate

: 258850-20-3
(+/-)-methyl 2-[[(2-amino-5-chlorophenyl)methyl]amino]-3-methylbutanoate

Guidance literature:: With hydrazine hydrate; RaNi; In methanol; for 4h; Heating;
DOI:10.1016/S0968-0896(99)00198-4

Reference yield:

: 73033-58-6
5-chloro-2-nitrobenzyl alcohol

: 258850-20-3
(+/-)-methyl 2-[[(2-amino-5-chlorophenyl)methyl]amino]-3-methylbutanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / Et₃N / toluene / 2 h / 5 °C

2: 89 percent / Et₃N / tetrahydrofuran / 72 h / Heating

3: 89 percent / hydrazine hydrate / RaNi / methanol / 4 h / Heating

With hydrazine hydrate; triethylamine; RaNi; In tetrahydrofuran; methanol; toluene; 1: Esterification / 2: Substitution / 3: Reduction;
DOI:10.1016/S0968-0896(99)00198-4

Reference yield:

: 5619-05-6,6306-52-1,7146-15-8
DL-valine methyl ester hydrochloride

: 258850-20-3
(+/-)-methyl 2-[[(2-amino-5-chlorophenyl)methyl]amino]-3-methylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / Et₃N / tetrahydrofuran / 72 h / Heating

2: 89 percent / hydrazine hydrate / RaNi / methanol / 4 h / Heating

With hydrazine hydrate; triethylamine; RaNi; In tetrahydrofuran; methanol; 1: Substitution / 2: Reduction;
DOI:10.1016/S0968-0896(99)00198-4