N-α,N-ω-,N-ω′-Tri-Z-D-arginine

Base Information

• Chemical Name: N-α,N-ω-,N-ω′-Tri-Z-D-arginine
• CAS No.: 1947-42-8
• Molecular Formula: C30H32N4O8
• Molecular Weight: 576.606
• Mol file: 1947-42-8.mol

Synonyms:2-Oxa-4,6,11-triazadodec-4-en-12-oicacid, 10-carboxy-3-oxo-1-phenyl-5-[[(phenylmethoxy)carbonyl]amino]-,12-(phenylmethyl) ester, (R)-;Ornithine,N2-carboxy-N5-(N,N'-dicarboxyamidino)-, tribenzyl ester, D- (8CI);

Chemical Property of N-α,N-ω-,N-ω′-Tri-Z-D-arginine

Chemical Property:

• Melting Point: 137-140 °C
• PKA: 3.89±0.21(Predicted)
• PSA: 167.35000
• Density: 1.27±0.1 g/cm3(Predicted)
• LogP: 5.52770
• Storage Temp.: Store at 0°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Nα,Nω,Nω'-Tris-Z-D-arginine,≥98%(TLC) ≥98%(TLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-α,N-ω-,N-ω′-Tri-Z-D-arginine

There total 3 articles about N-α,N-ω-,N-ω′-Tri-Z-D-arginine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C33H40N4O8Si → Nα,Nω,Nω'-Tris(benzyloxycarbonyl)-L-arginin (1947-42-8,20888-05-5)

Guidance literature:

With methanol; In dichloromethane; for 0.25h; Yield given; Ambient temperature;

DOI:10.1016/0040-4039(96)00299-7

Reference yield:

Nα-benzyloxycarbonyl-L-ornithine hydrochloride (92455-59-9) → Nα,Nω,Nω'-Tris(benzyloxycarbonyl)-L-arginin (1947-42-8,20888-05-5)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

2: Et₃N / CH₂Cl₂ / 12 h / Heating

3: MeOH / CH₂Cl₂ / 0.25 h / Ambient temperature

With methanol; triethylamine; In dichloromethane;

DOI:10.1016/0040-4039(96)00299-7

Reference yield:

C16H26N2O4Si*ClH → Nα,Nω,Nω'-Tris(benzyloxycarbonyl)-L-arginin (1947-42-8,20888-05-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 12 h / Heating

2: MeOH / CH₂Cl₂ / 0.25 h / Ambient temperature

With methanol; triethylamine; In dichloromethane;

DOI:10.1016/0040-4039(96)00299-7

upstream raw materials:

N^α-benzyloxycarbonyl-L-ornithine hydrochloride

Downstream raw materials:

tert-butyl N₂-[(benzyloxy)carbonyl]-N₅-(N,N'-bis[(benzyloxy)carbonyl]carbamimidoyl)-D-ornithyl-N₅-(4-[(2-tert-butyl-6-methoxyquinolin-8-yl)amino]pentyl)-L-glutaminate

tert-butyl N₂-[(benzyloxy)carbonyl]-N₅-(N,N'-bis[(benzyloxy)carbonyl]carbamimidoyl)-D-ornithyl-N₄-(4-[(6-methoxyquinolin-8-yl)amino]pentyl)-L-asparaginate

tert-butyl N₂-[(benzyloxy)carbonyl]-N₅-(N,N'-bis[(benzyloxy)carbonyl]carbamimidoyl)-L-ornithyl-N₅-(4-[(2-tert-butyl-6-methoxyquinolin-8-yl)amino]pentyl)-D-glutaminate

tert-butyl N₂-[(benzyloxy)carbonyl]-N₅-(N,N'-bis[(benzyloxy)carbonyl]carbamimidoyl)-L-ornithyl-N₄-(4-[(2-tert-butyl-6-methoxyquinolin-8-yl)amino]pentyl)-D-asparaginate