5-Amino-2,3-dichloropyridine

Base Information

• Chemical Name: 5-Amino-2,3-dichloropyridine
• CAS No.: 98121-41-6
• Molecular Formula: C5H4Cl2N2
• Molecular Weight: 163.006
• Hs Code.: 29333999
• European Community (EC) Number: 689-450-2
• DSSTox Substance ID: DTXSID10562008
• Wikidata: Q72435774
• Mol file: 98121-41-6.mol

Synonyms:98121-41-6;5-Amino-2,3-dichloropyridine;5,6-dichloropyridin-3-amine;3-Amino-5,6-dichloropyridine;3-Pyridinamine, 5,6-dichloro-;5,6-dichloro-3-pyridinamine;MFCD03840434;5-Amino-2.3-dichloropyridine;SCHEMBL195850;5,6-dichloropyridine-3-amine;5,6-Dichloropyridin-3-ylamine;DTXSID10562008;GEO-03657;5-Amino-2,3-dichloropyridine, 98%;5-Amino-2.3-dichloropyridine, 97%;AKOS005257571;AC-1176;CS-W010849;GS-5052;SB76339;SY022518;AM20070155;EN300-93603;J-516518

Chemical Property of 5-Amino-2,3-dichloropyridine

Chemical Property:

• Appearance/Colour: Light yellow powder
• Melting Point: 107-112℃
• Boiling Point: 321.3 °C at 760 mmHg
• PKA: 0.88±0.10(Predicted)
• Flash Point: 148.1 °C
• PSA: 38.91000
• Density: 1.497 g/cm³
• LogP: 2.55180
• Storage Temp.: Room temperature.
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 161.9751535
• Heavy Atom Count: 9
• Complexity: 99

Purity/Quality:

99% ^*data from raw suppliers

5-Amino-2,3-dichloropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 36/37/38-41-37/38-25
• Safety Statements: 26-36/37-36-45-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=NC(=C1Cl)Cl)N
• Uses: 5-Amino-2,3-dichloropyridine is a useful research reagent for organic synthesis.

Technology Process of 5-Amino-2,3-dichloropyridine

There total 1 articles about 5-Amino-2,3-dichloropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-N-(5,6-dichloropyridin-3-yl)-1-(1H-indazol-5-yl)methanimine (1619884-78-4) → 1H-indazole-5-carbaldehyde (253801-04-6) + 5-Amino-2,3-dichloropyridine (98121-41-6)

Guidance literature:

In methanol; at 20 ℃; for 1488h;

DOI:10.1016/j.ejmech.2019.06.041

Reference yield: 80.0%

5-Amino-2,3-dichloropyridine (98121-41-6) → 5,6-dichloropyridine-3-sulfonyl chloride (98121-40-5)

Guidance literature:

5-Amino-2,3-dichloropyridine; With hydrogenchloride; sodium nitrite; In water; Cooling with ice;

With hydrogenchloride; copper(I) sulfate; sodium sulfite; In water; Cooling with ice;

Reference yield: 76.0%

5-Amino-2,3-dichloropyridine (98121-41-6) + 3,4-dichlorophenylisocyanate (102-36-3) → C12H7Cl4N3O

Guidance literature:

In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2016.01.075

upstream raw materials:

(E)-N-(5,6-dichloropyridin-3-yl)-1-(1H-indazol-5-yl)methanimine

Downstream raw materials:

5.6-Dichloro-3-hydroxypyridine

5-bromo-2,3-dichloropyridine

2,3-dichloro -5-fluoropyridine

2,3-dichloro-5-iodopyridine