3-[2-[4-(2-chlorophenyl)piperazin-1-yl]ethyl]-6-(2-furanyl)-1,5-dihydropyrrolo[3,2-d]pyrimidine-2,4-dione

Base Information

Chemical Name:3-[2-[4-(2-chlorophenyl)piperazin-1-yl]ethyl]-6-(2-furanyl)-1,5-dihydropyrrolo[3,2-d]pyrimidine-2,4-dione
CAS No.:1335106-61-0
Molecular Formula:C₂₂H₂₂ClN₅O₃
Molecular Weight:439.901
Hs Code.:

Synonyms:3-[2-[4-(2-chlorophenyl)piperazin-1-yl]ethyl]-6-(2-furanyl)-1,5-dihydropyrrolo[3,2-d]pyrimidine-2,4-dione

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Chemical Property of 3-[2-[4-(2-chlorophenyl)piperazin-1-yl]ethyl]-6-(2-furanyl)-1,5-dihydropyrrolo[3,2-d]pyrimidine-2,4-dione

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Technology Process of 3-[2-[4-(2-chlorophenyl)piperazin-1-yl]ethyl]-6-(2-furanyl)-1,5-dihydropyrrolo[3,2-d]pyrimidine-2,4-dione

There total 2 articles about 3-[2-[4-(2-chlorophenyl)piperazin-1-yl]ethyl]-6-(2-furanyl)-1,5-dihydropyrrolo[3,2-d]pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₂₈ClN₅O₄

: 1335106-61-0
3-[2-[4-(2-chlorophenyl)piperazin-1-yl]ethyl]-6-(2-furanyl)-1,5-dihydropyrrolo[3,2-d]pyrimidine-2,4-dione

Guidance literature:: C₂₄H₂₈ClN₅O₄; With potassium hydroxide; In methanol; for 2h; Reflux;

With acetic acid; In methanol; at 22 ℃; pH=4;
DOI:10.1016/j.bmc.2011.06.043

Reference yield:

: 237435-96-0
ethyl 3-amino-5-(2-furanyl)-1H-pyrrole-2-carboxylate

: 1335106-61-0
3-[2-[4-(2-chlorophenyl)piperazin-1-yl]ethyl]-6-(2-furanyl)-1,5-dihydropyrrolo[3,2-d]pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene / 16 h / 22 °C

2.1: sodium hydrogencarbonate; sodium iodide / isopropyl alcohol / 96 h / Reflux

3.1: potassium hydroxide / methanol / 2 h / Reflux

3.2: 22 °C / pH 4

With sodium hydrogencarbonate; sodium iodide; potassium hydroxide; In methanol; isopropyl alcohol; toluene;
DOI:10.1016/j.bmc.2011.06.043