methyl 4-(4-(methoxycarbonyl)phenyl)-2-tosyl-2,3-dihydro-1H-benzo[f]isoindole-6-carboxylate

Base Information

• Chemical Name: methyl 4-(4-(methoxycarbonyl)phenyl)-2-tosyl-2,3-dihydro-1H-benzo[f]isoindole-6-carboxylate
• CAS No.: 1410674-66-6
• Molecular Formula: C₂₉H₂₅NO₆S
• Molecular Weight: 515.587
• Mol file: 1410674-66-6.mol

Synonyms:methyl 4-(4-(methoxycarbonyl)phenyl)-2-tosyl-2,3-dihydro-1H-benzo[f]isoindole-6-carboxylate

Chemical Property of methyl 4-(4-(methoxycarbonyl)phenyl)-2-tosyl-2,3-dihydro-1H-benzo[f]isoindole-6-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-(4-(methoxycarbonyl)phenyl)-2-tosyl-2,3-dihydro-1H-benzo[f]isoindole-6-carboxylate

There total 2 articles about methyl 4-(4-(methoxycarbonyl)phenyl)-2-tosyl-2,3-dihydro-1H-benzo[f]isoindole-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C29H25NO6S → methyl 4-(4-(methoxycarbonyl)phenyl)-2-tosyl-2,3-dihydro-1H-benzo[f]isoindole-6-carboxylate (1410674-66-6)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; for 48h; Reflux; Inert atmosphere;

DOI:10.1039/c4ra10503f

Reference yield: 35.0%

methyl 4-iodobenzoate (619-44-3) + 4-methyl-N,N-diprop-2-ynylbenzenesulfonamide (18773-54-1) → methyl 4-(4-(methoxycarbonyl)phenyl)-2-tosyl-2,3-dihydro-1H-benzo[f]isoindole-6-carboxylate (1410674-66-6)

Guidance literature:

methyl 4-iodobenzoate; 4-methyl-N,N-diprop-2-ynylbenzenesulfonamide; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 20 ℃; for 0.5h; Schlenk technique; Inert atmosphere;

With DBN; In tetrahydrofuran; at 60 ℃; for 8h; Schlenk technique; Inert atmosphere;

DOI:10.1021/jo301437k

Reference yield: 90.0%

methyl 4-(4-(methoxycarbonyl)phenyl)-2-tosyl-2,3-dihydro-1H-benzo[f]isoindole-6-carboxylate (1410674-66-6) → C27H25NO4S

Guidance literature:

methyl 4-(4-(methoxycarbonyl)phenyl)-2-tosyl-2,3-dihydro-1H-benzo[f]isoindole-6-carboxylate; With sodium tetrahydroborate; In tetrahydrofuran; at 65 ℃; for 0.25h; Inert atmosphere;

In methanol; at 65 ℃; for 5h; Inert atmosphere;

DOI:10.1039/c4ra10503f

upstream raw materials:

methyl 4-iodobenzoate

4-methyl-N,N-diprop-2-ynylbenzenesulfonamide