1-Amino-1-cyclopentanecarboxamide

Base Information

• Chemical Name: 1-Amino-1-cyclopentanecarboxamide
• CAS No.: 17193-28-1
• Molecular Formula: C6H12N2O
• Molecular Weight: 128.174
• Hs Code.: 2924299090
• European Community (EC) Number: 422-950-9,687-187-8
• DSSTox Substance ID: DTXSID30455665
• Wikidata: Q72435370
• Mol file: 17193-28-1.mol

Synonyms:1-AMINO-1-CYCLOPENTANECARBOXAMIDE;17193-28-1;1-aminocyclopentane-1-carboxamide;1-Aminocyclopentanecarboxamide;MFCD01735313;EC 422-950-9;Irbesartan Intermediates;aminocyclopentanecarboxamide;1-Amino-cyclopentanecarboxamide;SCHEMBL1911324;1-Amino-1-carbamidocyclopentane;NIOSH/GY2556000;DTXSID30455665;Cyclopentanecarboxamide, 1-amino-;YGVGITVCEHRBDK-UHFFFAOYSA-N;1-azanylcyclopentane-1-carboxamide;AKOS005257407;CB 1705;CS-W005762;SB74313;1-Aminocyclopentane-1-carboxamide, 95%;DS-11008;LS-57840;AM20090025;FT-0601145;GY25560000;EN300-29626;F10420;A811366;J-504176

Chemical Property of 1-Amino-1-cyclopentanecarboxamide

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 95-96℃ (acetone pentane )
• Refractive Index: 1.524
• Boiling Point: 301.5 °C at 760 mmHg
• PKA: 16.14±0.20(Predicted)
• Flash Point: 136.142 °C
• PSA: 69.11000
• Density: 1.133 g/cm³
• LogP: 1.14380
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: -1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 128.094963011
• Heavy Atom Count: 9
• Complexity: 127

Purity/Quality:

99% ^*data from raw suppliers

1-Amino-1-cyclopentanecarboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 22-41-48/25
• Safety Statements: 22-26-36/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(C1)(C(=O)N)N
• Uses: 1-Amino-1-cyclopentanecarboxamide is a useful synthesis intermediate. An amino-cyclopentanecarboxamide derivative with pharmacological and tumor inhibiting activity.

Technology Process of 1-Amino-1-cyclopentanecarboxamide

There total 9 articles about 1-Amino-1-cyclopentanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-amino-cyclopentanecarbonitrile oxalate (711603-83-7) → 1-aminocyclopentane-1-carboxamide (17193-28-1)

Guidance literature:

With sulfuric acid; at 20 ℃; for 0.75h;

DOI:10.1016/j.tetlet.2008.02.147

Reference yield: 76.2%

→ 1-aminocyclopentane-1-carboxamide (17193-28-1)

Guidance literature:

Reference yield: 27.0%

1-amino-1-cyanocyclopentane (49830-37-7) → 1-aminocyclopentane-1-carboxamide (17193-28-1)

Guidance literature:

1-amino-1-cyanocyclopentane; With sulfuric acid; In dichloromethane; at 15 - 40 ℃; for 1h;

With ammonia; In dichloromethane; water; at 0 ℃; pH=7 - 8;

upstream raw materials:

Dimeres 1-Cyan-1-trichlorphosphoranylidenamino-cyclopentan

1-(Benzyloxycarbonylamino)-cyclopentan-1-carbonsaeureamid

1-amino-cyclopentanecarboxylic acid ethyl ester hydrochloride

1-aminocyclopentanecarbonitrile hydrochloride

Downstream raw materials:

1-(pentanoylamino)cyclopentanecarboxamide

1-(2-Benzyloxyacetamido)-cyclopentyl-1-carboxamide

2-butyl-1,3-diaza-spiro[4.4]non-1-en-4one

2-benzyl-1,3-diazaspiro[4.4]non-1-en-4-one

Refernces

• 1、 -. "Methods and compositions for treating amyloid-related diseases". Page/Page column 157. . Retrieved 2010/11/24.
• 2、 -. "Process for the preparation of cyclic 4-oxoamidines". . . Retrieved 2008/06/13.