(Z)-2-(5-Chloro-2-nitro-phenyl)-3-dimethylamino-1-(2-fluoro-phenyl)-propenone

Base Information

• Chemical Name: (Z)-2-(5-Chloro-2-nitro-phenyl)-3-dimethylamino-1-(2-fluoro-phenyl)-propenone
• CAS No.: 80805-69-2
• Molecular Formula: C₁₇H₁₄ClFN₂O₃
• Molecular Weight: 348.761
• Mol file: 80805-69-2.mol

Synonyms:(Z)-2-(5-Chloro-2-nitro-phenyl)-3-dimethylamino-1-(2-fluoro-phenyl)-propenone

Chemical Property of (Z)-2-(5-Chloro-2-nitro-phenyl)-3-dimethylamino-1-(2-fluoro-phenyl)-propenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-2-(5-Chloro-2-nitro-phenyl)-3-dimethylamino-1-(2-fluoro-phenyl)-propenone

There total 1 articles about (Z)-2-(5-Chloro-2-nitro-phenyl)-3-dimethylamino-1-(2-fluoro-phenyl)-propenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloro-2-nitrotoluene (5367-28-2) + 2-Fluorobenzoyl chloride (393-52-2) + N,N-dimethylformamide diethyl diacetal (1188-33-6) → (Z)-2-(5-Chloro-2-nitro-phenyl)-3-dimethylamino-1-(2-fluoro-phenyl)-propenone (80805-69-2)

Guidance literature:

With triethylamine; Multistep reaction; 2.) toluene, reflux, 15 h;

DOI:10.1021/jm00346a004

Reference yield: 26.0%

(Z)-2-(5-Chloro-2-nitro-phenyl)-3-dimethylamino-1-(2-fluoro-phenyl)-propenone (80805-69-2) → 2-(5-Chloro-2-nitro-phenyl)-1-(2-fluoro-phenyl)-ethanone (80805-56-7)

Guidance literature:

With water; In 1,4-dioxane; Heating;

DOI:10.1021/jm00346a004

Reference yield:

(Z)-2-(5-Chloro-2-nitro-phenyl)-3-dimethylamino-1-(2-fluoro-phenyl)-propenone (80805-69-2) → 4-Chloro-2-[2-(2-fluoro-phenyl)-2-methylamino-ethyl]-phenylamine (700797-17-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 26 percent / water / dioxane / Heating

2: 1.) titanium tetrachloride, 2.) ethereal hydrogen chloride, sodium cyanoborohydride / 1.) a) toluene, from -40 deg C to RT, 0.5 h, b) 80 deg C, 5 h, c) RT, overnight, 2.) methanol, RT, 0.5 h

3: iron, concd. hydrochloric acid / ethanol; H₂O

With hydrogenchloride; water; titanium tetrachloride; iron; sodium cyanoborohydride; In 1,4-dioxane; ethanol; water;

DOI:10.1021/jm00346a004

upstream raw materials:

5-chloro-2-nitrotoluene

2-Fluorobenzoyl chloride

N,N-dimethylformamide diethyl diacetal

Downstream raw materials:

2-(5-Chloro-2-nitro-phenyl)-1-(2-fluoro-phenyl)-ethanone

4-Chloro-2-[2-(2-fluoro-phenyl)-2-methylamino-ethyl]-phenylamine

7-chloro-4,5-dihydro-2,3-dimethyl-4-(2-fluorophenyl)-3H-1,3-benzodiazepine

[2-(5-Chloro-2-nitro-phenyl)-1-(2-fluoro-phenyl)-ethyl]-methyl-amine