4-(9-Benzyl-9H-β-carbolin-1-yl)-4-(tert-butyl-dimethyl-silanyloxy)-butane-1,2-diol

Base Information

Chemical Name:4-(9-Benzyl-9H-β-carbolin-1-yl)-4-(tert-butyl-dimethyl-silanyloxy)-butane-1,2-diol
CAS No.:203717-22-0
Molecular Formula:C₂₈H₃₆N₂O₃Si
Molecular Weight:476.691
Hs Code.:

Synonyms:4-(9-Benzyl-9H-β-carbolin-1-yl)-4-(tert-butyl-dimethyl-silanyloxy)-butane-1,2-diol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(9-Benzyl-9H-β-carbolin-1-yl)-4-(tert-butyl-dimethyl-silanyloxy)-butane-1,2-diol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-(9-Benzyl-9H-β-carbolin-1-yl)-4-(tert-butyl-dimethyl-silanyloxy)-butane-1,2-diol

There total 6 articles about 4-(9-Benzyl-9H-β-carbolin-1-yl)-4-(tert-butyl-dimethyl-silanyloxy)-butane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 203717-20-8
9-Benzyl-1-[1-(tert-butyl-dimethyl-silanyloxy)-but-3-enyl]-9H-β-carboline

: 203717-22-0
4-(9-Benzyl-9H-β-carbolin-1-yl)-4-(tert-butyl-dimethyl-silanyloxy)-butane-1,2-diol

Guidance literature:: With osmium(VIII) oxide; In tetrahydrofuran; pyridine; for 3h; Ambient temperature;
DOI:10.1016/S0223-5234(97)89645-6

Reference yield:

: 3464-66-2
methyl 9H-pyrido[3,4-b]indole-1-carboxylate

: 203717-22-0
4-(9-Benzyl-9H-β-carbolin-1-yl)-4-(tert-butyl-dimethyl-silanyloxy)-butane-1,2-diol

Guidance literature:: Multi-step reaction with 5 steps

1: 88.6 percent / NaH / hexamethylphosphoric acid triamide / 0 deg C to r.t., overnight

2: 72 percent / DIBAL-H / toluene / -78 °C

3: 75 percent / I₂ / tetrahydrofuran; diethyl ether / 4 h / -20 deg C to r.t.

4: 80 percent / AgNO₃ / pyridine / 0.5 h / Ambient temperature

5: 93 percent / OsO₄ / pyridine; tetrahydrofuran / 3 h / Ambient temperature

With osmium(VIII) oxide; iodine; sodium hydride; diisobutylaluminium hydride; silver nitrate; In tetrahydrofuran; pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; toluene;
DOI:10.1016/S0223-5234(97)89645-6

Reference yield:

: 100-44-7
benzyl chloride

: 203717-22-0
4-(9-Benzyl-9H-β-carbolin-1-yl)-4-(tert-butyl-dimethyl-silanyloxy)-butane-1,2-diol

Guidance literature:: Multi-step reaction with 5 steps

1: 88.6 percent / NaH / hexamethylphosphoric acid triamide / 0 deg C to r.t., overnight

2: 72 percent / DIBAL-H / toluene / -78 °C

3: 75 percent / I₂ / tetrahydrofuran; diethyl ether / 4 h / -20 deg C to r.t.

4: 80 percent / AgNO₃ / pyridine / 0.5 h / Ambient temperature

5: 93 percent / OsO₄ / pyridine; tetrahydrofuran / 3 h / Ambient temperature

With osmium(VIII) oxide; iodine; sodium hydride; diisobutylaluminium hydride; silver nitrate; In tetrahydrofuran; pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; toluene;
DOI:10.1016/S0223-5234(97)89645-6