N-[(3S)-5-pyridin-4-yl-3,4-dihydro-2H-chromen-3-yl]-4-(trifluoromethoxy)-benzamide

Base Information

Chemical Name:N-[(3S)-5-pyridin-4-yl-3,4-dihydro-2H-chromen-3-yl]-4-(trifluoromethoxy)-benzamide
CAS No.:1072852-42-6
Molecular Formula:C₂₂H₁₇F₃N₂O₃
Molecular Weight:414.384
Hs Code.:

Synonyms:N-[(3S)-5-pyridin-4-yl-3,4-dihydro-2H-chromen-3-yl]-4-(trifluoromethoxy)-benzamide

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Chemical Property of N-[(3S)-5-pyridin-4-yl-3,4-dihydro-2H-chromen-3-yl]-4-(trifluoromethoxy)-benzamide

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Technology Process of N-[(3S)-5-pyridin-4-yl-3,4-dihydro-2H-chromen-3-yl]-4-(trifluoromethoxy)-benzamide

There total 9 articles about N-[(3S)-5-pyridin-4-yl-3,4-dihydro-2H-chromen-3-yl]-4-(trifluoromethoxy)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1072854-58-0
(S)-5-(pyridin-4-yl)chroman-3-amine

: 36823-88-8
4-(trifluoromethoxy)benzoyl chloride

: 1072852-42-6
N-[(3S)-5-pyridin-4-yl-3,4-dihydro-2H-chromen-3-yl]-4-(trifluoromethoxy)-benzamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 0.0833333 - 0.5h;

Reference yield:

: 221184-57-2
(3S)-3-(dibenzylamino)chroman-5-ol

: 1072852-42-6
N-[(3S)-5-pyridin-4-yl-3,4-dihydro-2H-chromen-3-yl]-4-(trifluoromethoxy)-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 0 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / N,N-dimethyl-formamide / Heating

3: palladium 10% on activated carbon; ammonium formate / ethanol / Heating

4: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; ammonium formate; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2012.06.105

Reference yield:

: 1072854-56-8
(3S)-N,N-dibenzyl-5-pyridin-4-ylchroman-3-amine

: 1072852-42-6
N-[(3S)-5-pyridin-4-yl-3,4-dihydro-2H-chromen-3-yl]-4-(trifluoromethoxy)-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; ammonium formate / ethanol / Heating

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide

With palladium 10% on activated carbon; ammonium formate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.06.105