2,4,6-Trifluoro-D-Phenylalanine

Base Information

• Chemical Name: 2,4,6-Trifluoro-D-Phenylalanine
• CAS No.: 146277-48-7
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.272
• Mol file: 146277-48-7.mol

Synonyms:D-2,4,6-Trimethylphenylalanine

Chemical Property of 2,4,6-Trifluoro-D-Phenylalanine

Chemical Property:

• PSA: 63.32000
• LogP: 2.26650

Purity/Quality:

98% Min ^*data from raw suppliers

(R)-2-Amino-3-(2,4,6-trimethyl-phenyl)-propionicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4,6-Trifluoro-D-Phenylalanine

There total 6 articles about 2,4,6-Trifluoro-D-Phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-Acetylamino-3-(2,4,6-trimethyl-phenyl)-propionic acid (82317-70-2) → 2,4,6-trimethyl-phenylalanine (76932-42-8,146277-48-7)

Guidance literature:

With hydrogenchloride; for 2h; Heating;

DOI:10.1021/jm00349a006

Reference yield: 80.0%

(2S)-mesitylalanine ethyl ester → 2',4',6'-trimethyl-L-phenylalanine (146277-47-6,146277-48-7)

Guidance literature:

With lithium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 24h;

DOI:10.1016/j.tetasy.2007.10.041

Reference yield:

→ 2,4,6-trimethyl-phenylalanine (76932-42-8,146277-48-7)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/ja01572a065

upstream raw materials:

2-Acetylamino-3-(2,4,6-trimethyl-phenyl)-propionic acid

diethyl 2,4,6-trimethylbenzylacetamidomalonate

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