(R)-2-(((Benzyloxy)carbonyl)amino)-2-cyclohexylacetic acid

Base Information

Chemical Name:(R)-2-(((Benzyloxy)carbonyl)amino)-2-cyclohexylacetic acid
CAS No.:69901-85-5
Molecular Formula:C16H21NO4
Molecular Weight:291.347
Hs Code.:2924299090
DSSTox Substance ID:DTXSID50561116
Nikkaji Number:J2.210.428D
Wikidata:Q72502134

Synonyms:Z-D-Chg-OH;69901-85-5;(R)-2-(((Benzyloxy)carbonyl)amino)-2-cyclohexylacetic acid;Cbz-D-cyclohexyl glycine;(2R)-2-cyclohexyl-2-(phenylmethoxycarbonylamino)acetic acid;Z-cyclohexyl-D-Gly-OH;N-Z-D-|A-Cyclohexylglycine;MFCD00191082;SCHEMBL433978;(R)-2-(benzyloxycarbonylamino)-2-cyclohexylacetic acid;DTXSID50561116;CUSYTUPJAYLNFQ-CQSZACIVSA-N;BCP13869;CS-B1518;AKOS015888883;AC-24035;DS-18393;HY-77635;Z-D-Chg-OH, >=98.0% (TLC);F14548;(R)-benzyloxycarbonylamino-cyclohexyl-acetic acid;EN300-7390051;(2R)-{[(Benzyloxy)carbonyl]amino}(cyclohexyl)acetic acid;(2R)-2-{[(benzyloxy)carbonyl]amino}-2-cyclohexylacetic acid

Suppliers and Price of (R)-2-(((Benzyloxy)carbonyl)amino)-2-cyclohexylacetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Z-D-2-cyclohexylglycine
2g
$ 343.00

TRC
(R)-2-(((Benzyloxy)carbonyl)amino)-2-cyclohexylaceticAcid
250mg
$ 55.00

Sigma-Aldrich
Z-D-Chg-OH ≥98.0% (TLC)
1g
$ 112.00

Crysdot
Z-D-Chg-OH 95+%
25g
$ 163.00

ChemScene
Cyclohexaneaceticacid,α-[[(phenylmethoxy)carbonyl]amino]-,(αR)-
10g
$ 72.00

ChemScene
Cyclohexaneaceticacid,α-[[(phenylmethoxy)carbonyl]amino]-,(αR)-
25g
$ 146.00

Chem-Impex
Z-D-2-cyclohexylglycine ≥ 98% (HPLC)
1G
$ 40.00

Chem-Impex
Z-D-2-cyclohexylglycine ≥ 98% (HPLC)
25G
$ 525.00

Chem-Impex
Z-D-2-cyclohexylglycine ≥ 98% (HPLC)
5G
$ 165.00

American Custom Chemicals Corporation
Z-D-CHG-OH 95.00%
5G
$ 1018.71

Total 43 raw suppliers

Chemical Property of (R)-2-(((Benzyloxy)carbonyl)amino)-2-cyclohexylacetic acid

Chemical Property:

Melting Point:103℃
Boiling Point:492.1 °C at 760 mmHg
PKA:3.99±0.10(Predicted)
Flash Point:251.4 °C
PSA：79.12000
Density:1.2 g/cm³
LogP:3.15070
Storage Temp.:2-8°C
XLogP3:3.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:291.14705815
Heavy Atom Count:21
Complexity:346

Purity/Quality:

97% ^*data from raw suppliers

Z-D-2-cyclohexylglycine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC(CC1)C(C(=O)O)NC(=O)OCC2=CC=CC=C2
Isomeric SMILES:C1CCC(CC1)[C@H](C(=O)O)NC(=O)OCC2=CC=CC=C2

Technology Process of (R)-2-(((Benzyloxy)carbonyl)amino)-2-cyclohexylacetic acid

There total 7 articles about (R)-2-(((Benzyloxy)carbonyl)amino)-2-cyclohexylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-(benzyloxycarbonyl)-α-dehydrocyclohexylglycine

: 69901-75-3
(S)-[[(benzyloxy)carbonyl]amino](cyclohexyl)acetic acid

: 69901-85-5
(R)-N-benzyloxycarbonylcyclohexylglicine

Guidance literature:: With (R)-(-)-[(S)-2-(diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; hydrogen; triethylamine; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; In ethanol; 1,2-dichloro-ethane; at 25 ℃; for 24h; under 4654.33 Torr; Title compound not separated from byproducts;
DOI:10.1021/ol050869s

Reference yield:

: 621-84-1
O-benzyl carbamate

: 69901-85-5
(R)-N-benzyloxycarbonylcyclohexylglicine

Guidance literature:: Multi-step reaction with 2 steps

1: 43 percent / methanesulfonic acid / toluene / 2 h / Heating

2: H₂; (R)-(S)-1-Ph₃P-2-(CHMeP(t-Bu)2)ferrocene; Et₃N / [(p-cymene)RuCl₂]2 / ethanol; 1,2-dichloro-ethane / 24 h / 25 °C / 4654.33 Torr

With methanesulfonic acid; (R)-(-)-[(S)-2-(diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; hydrogen; triethylamine; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; In ethanol; 1,2-dichloro-ethane; toluene;
DOI:10.1021/ol050869s

Reference yield:

: 4354-49-8
2-cyclohexyl-2-oxoethanoic acid

: 69901-85-5
(R)-N-benzyloxycarbonylcyclohexylglicine

Guidance literature:: Multi-step reaction with 2 steps

1: 43 percent / methanesulfonic acid / toluene / 2 h / Heating

2: H₂; (R)-(S)-1-Ph₃P-2-(CHMeP(t-Bu)2)ferrocene; Et₃N / [(p-cymene)RuCl₂]2 / ethanol; 1,2-dichloro-ethane / 24 h / 25 °C / 4654.33 Torr

With methanesulfonic acid; (R)-(-)-[(S)-2-(diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; hydrogen; triethylamine; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; In ethanol; 1,2-dichloro-ethane; toluene;
DOI:10.1021/ol050869s