6-[4-(2-methoxyphenyl)-1-piperazinyl]-5-isopropyluracil

Base Information

• Chemical Name: 6-[4-(2-methoxyphenyl)-1-piperazinyl]-5-isopropyluracil
• CAS No.: 1310053-32-7
• Molecular Formula: C₁₈H₂₄N₄O₃
• Molecular Weight: 344.414
• Mol file: 1310053-32-7.mol

Synonyms:6-[4-(2-methoxyphenyl)-1-piperazinyl]-5-isopropyluracil

Chemical Property of 6-[4-(2-methoxyphenyl)-1-piperazinyl]-5-isopropyluracil

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-[4-(2-methoxyphenyl)-1-piperazinyl]-5-isopropyluracil

There total 4 articles about 6-[4-(2-methoxyphenyl)-1-piperazinyl]-5-isopropyluracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-(2-Methoxyphenyl)piperazine (35386-24-4) + 5-isopropyl-6-chloro-2,4-pyrimidinedione (96796-80-4) → 6-[4-(2-methoxyphenyl)-1-piperazinyl]-5-isopropyluracil (1310053-32-7)

Guidance literature:

With potassium carbonate; In ethanol; for 6h; Reflux;

DOI:10.3390/molecules16064764

Reference yield:

diethyl isopropylmalonate (759-36-4) → 6-[4-(2-methoxyphenyl)-1-piperazinyl]-5-isopropyluracil (1310053-32-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium methylate / methanol / 0.5 h / Reflux

1.2: 10 h / Reflux

2.1: N,N-dimethyl-aniline; trichlorophosphate / 1 h / Reflux

3.1: water; sodium hydroxide / 0.5 h / Reflux

4.1: potassium carbonate / ethanol / 6 h / Reflux

With water; sodium methylate; potassium carbonate; N,N-dimethyl-aniline; sodium hydroxide; trichlorophosphate; In methanol; ethanol;

DOI:10.3390/molecules16064764

Reference yield:

5-isopropylbarbituric acid (7391-69-7) → 6-[4-(2-methoxyphenyl)-1-piperazinyl]-5-isopropyluracil (1310053-32-7)

Guidance literature:

Multi-step reaction with 3 steps

1: N,N-dimethyl-aniline; trichlorophosphate / 1 h / Reflux

2: water; sodium hydroxide / 0.5 h / Reflux

3: potassium carbonate / ethanol / 6 h / Reflux

With water; potassium carbonate; N,N-dimethyl-aniline; sodium hydroxide; trichlorophosphate; In ethanol;

DOI:10.3390/molecules16064764

upstream raw materials:

diethyl isopropylmalonate

5-isopropylbarbituric acid

1-(2-Methoxyphenyl)piperazine

5-isopropyl-6-chloro-2,4-pyrimidinedione

Refernces