1-(4-Chlorophenyl)-3-hydroxymethylpiperidine

Base Information

Chemical Name:1-(4-Chlorophenyl)-3-hydroxymethylpiperidine
CAS No.:133749-00-5
Molecular Formula:C₁₂H₁₆ClNO
Molecular Weight:225.718
Hs Code.:
European Community (EC) Number:887-925-0

Synonyms:[1-(4-chlorophenyl)piperidin-3-yl]methanol;133749-00-5;1-(4-chlorophenyl)-3-hydroxymethylpiperidine;SCHEMBL6271445;EN300-249716

Suppliers and Price of 1-(4-Chlorophenyl)-3-hydroxymethylpiperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 1-(4-Chlorophenyl)-3-hydroxymethylpiperidine

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:225.0920418
Heavy Atom Count:15
Complexity:192

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC(CN(C1)C2=CC=C(C=C2)Cl)CO

Technology Process of 1-(4-Chlorophenyl)-3-hydroxymethylpiperidine

There total 4 articles about 1-(4-Chlorophenyl)-3-hydroxymethylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.3%

: 133748-62-6
1-(4-chlorophenyl)-6-oxo-piperidine-3-carboxylic acid

: 133749-00-5
1-(4-Chlorophenyl)-3-hydroxymethylpiperidine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 20h; Heating;
DOI:10.1016/0223-5234(94)90029-9

Reference yield:

: 3621-79-2
2-methyleneglutaric acid

: 133749-00-5
1-(4-Chlorophenyl)-3-hydroxymethylpiperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 75.6 percent / Heating

2: 97.3 percent / LiAlH₄ / tetrahydrofuran / 20 h / Heating

With lithium aluminium tetrahydride; In tetrahydrofuran;
DOI:10.1016/0223-5234(94)90029-9

Reference yield:

: 106-47-8
4-chloro-aniline

: 133749-00-5
1-(4-Chlorophenyl)-3-hydroxymethylpiperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 75.6 percent / Heating

2: 97.3 percent / LiAlH₄ / tetrahydrofuran / 20 h / Heating

With lithium aluminium tetrahydride; In tetrahydrofuran;
DOI:10.1016/0223-5234(94)90029-9