(E)-3-[4-(2-Hydroxy-ethyl)-8-phenoxy-naphthalen-2-yl]-acrylic acid ethyl ester

Base Information

Chemical Name:(E)-3-[4-(2-Hydroxy-ethyl)-8-phenoxy-naphthalen-2-yl]-acrylic acid ethyl ester
CAS No.:181259-27-8
Molecular Formula:C₂₃H₂₂O₄
Molecular Weight:362.425
Hs Code.:

Synonyms:(E)-3-[4-(2-Hydroxy-ethyl)-8-phenoxy-naphthalen-2-yl]-acrylic acid ethyl ester

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Chemical Property of (E)-3-[4-(2-Hydroxy-ethyl)-8-phenoxy-naphthalen-2-yl]-acrylic acid ethyl ester

Chemical Property:

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Technology Process of (E)-3-[4-(2-Hydroxy-ethyl)-8-phenoxy-naphthalen-2-yl]-acrylic acid ethyl ester

There total 8 articles about (E)-3-[4-(2-Hydroxy-ethyl)-8-phenoxy-naphthalen-2-yl]-acrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19434-34-5
2-(phenoxy)benzaldehyde

: 181259-27-8
(E)-3-[4-(2-Hydroxy-ethyl)-8-phenoxy-naphthalen-2-yl]-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: KO-t-Bu / 2-methyl-propan-2-ol / 3 h / Heating

2: 6 h / Heating

3: methanol. NaOMe / 1 h / Ambient temperature

4: pyridine / CH₂Cl₂ / 1 h / 0 °C

5: 1.) LiCl, PdCl₂6H₅)3>2 / 1.) DMF, RT, 15 min, 2.) DMF, RT, 12 h

6: 1.) 9-BBN, 2.) aq. H₂O₂ / 1.) THF, RT, 48 h, 2.) THF, from 0 deg C to RT, 2 h

7: 4.4 g / LAH / tetrahydrofuran / 1 h / 5 - 10 °C

8: MnO₂ / CH₂Cl₂ / 18 h / Ambient temperature

9: 1.) NaH / 1.) THF, 0 deg C, 10 min, 2.) THF, RT, 5 h

With pyridine; manganese(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; lithium aluminium tetrahydride; 9-borabicyclo[3.3.1]nonane dimer; potassium tert-butylate; dihydrogen peroxide; sodium methylate; sodium hydride; lithium chloride; In tetrahydrofuran; dichloromethane; tert-butyl alcohol;
DOI:10.1021/jm950699x

Reference yield:

: 181259-01-8
8-Phenoxy-4-vinyl-naphthalene-2-carboxylic acid methyl ester

: 181259-27-8
(E)-3-[4-(2-Hydroxy-ethyl)-8-phenoxy-naphthalen-2-yl]-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 9-BBN, 2.) aq. H₂O₂ / 1.) THF, RT, 48 h, 2.) THF, from 0 deg C to RT, 2 h

2: 4.4 g / LAH / tetrahydrofuran / 1 h / 5 - 10 °C

3: MnO₂ / CH₂Cl₂ / 18 h / Ambient temperature

4: 1.) NaH / 1.) THF, 0 deg C, 10 min, 2.) THF, RT, 5 h

With manganese(IV) oxide; lithium aluminium tetrahydride; 9-borabicyclo[3.3.1]nonane dimer; dihydrogen peroxide; sodium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm950699x

Reference yield:

: 2-(3-Hydroxymethyl-5-phenoxy-naphthalen-1-yl)-ethanol

: 181259-27-8
(E)-3-[4-(2-Hydroxy-ethyl)-8-phenoxy-naphthalen-2-yl]-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: MnO₂ / CH₂Cl₂ / 18 h / Ambient temperature

2: 1.) NaH / 1.) THF, 0 deg C, 10 min, 2.) THF, RT, 5 h

With manganese(IV) oxide; sodium hydride; In dichloromethane;
DOI:10.1021/jm950699x