6-Bromomethyl-1,1-dimethyl-7-nitro-1,2,3,4-tetrahydro-naphthalene

Base Information

Chemical Name:6-Bromomethyl-1,1-dimethyl-7-nitro-1,2,3,4-tetrahydro-naphthalene
CAS No.:205385-88-2
Molecular Formula:C₁₃H₁₆BrNO₂
Molecular Weight:298.18
Hs Code.:

Synonyms:6-Bromomethyl-1,1-dimethyl-7-nitro-1,2,3,4-tetrahydro-naphthalene

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Chemical Property of 6-Bromomethyl-1,1-dimethyl-7-nitro-1,2,3,4-tetrahydro-naphthalene

Chemical Property:

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Technology Process of 6-Bromomethyl-1,1-dimethyl-7-nitro-1,2,3,4-tetrahydro-naphthalene

There total 1 articles about 6-Bromomethyl-1,1-dimethyl-7-nitro-1,2,3,4-tetrahydro-naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3123-97-5
dihydro-5,5-dimethyl-2(3H)-furanone

: 205385-88-2
6-Bromomethyl-1,1-dimethyl-7-nitro-1,2,3,4-tetrahydro-naphthalene

Guidance literature:: Multi-step reaction with 7 steps

1: 72 percent / AlCl₃ / 2.5 h / 90 - 100 °C

2: 65 percent / AlCl₃, Br₂ / CH₂Cl₂ / 0.5 h / 80 °C

3: 65 percent / CF₃COOH, triethylsilane / 8 h / 0 - 20 °C

4: 1.) n-BuLi / 1.) ether, hexane, RT, 40 min, 2.) ether, hexane, 0 def C, 20 min

5: NaBH₄ / methanol / 0.5 h / 0 °C

6: CHBr₃, Ph₃P / CH₂Cl₂ / 0.25 h / 0 °C

7: 32 percent / fuming HNO₃, AcOH, Ac₂O / 0.33 h / 0 °C

With triethylsilane; sodium tetrahydroborate; n-butyllithium; aluminium trichloride; Bromoform; bromine; nitric acid; acetic anhydride; acetic acid; triphenylphosphine; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1021/jm970704s

Reference yield:

: 205385-88-2
6-Bromomethyl-1,1-dimethyl-7-nitro-1,2,3,4-tetrahydro-naphthalene

: 205385-92-8
(S)-2-{[3-(2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-8,8-dimethyl-5,6,7,8-tetrahydro-naphthalen-2-yl]-methyl-amino}-3-methyl-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 97 percent / NaH / dimethylformamide / 2.5 h / Ambient temperature

2: conc. aq. HCl / acetic acid / 14 h / Heating

3: SOCl₂ / 20 h / Ambient temperature

4: CH₂Cl₂ / 18 h / Ambient temperature

5: LiBH₄ / tetrahydrofuran / 19 h / 0 - 20 °C

6: 92 percent / H₂ / 10percent Pd/C / ethanol / 6 h / 760 Torr / Ambient temperature

7: acetic anhydride / tetrahydrofuran / 2 h / 60 - 70 °C

8: BH₃ / tetrahydrofuran / 3 h / 0 °C

9: 82 percent / 2,6-lutidine / 1,2-dichloro-ethane / 48 h / Heating

With 2,6-dimethylpyridine; hydrogenchloride; lithium borohydride; thionyl chloride; borane; hydrogen; acetic anhydride; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm970704s