1-(4-(5-chloro-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylamino)-2,5-dimethylphenyl)ethanone O-2-hydroxyethyl oxime

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Chemical Name:1-(4-(5-chloro-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylamino)-2,5-dimethylphenyl)ethanone O-2-hydroxyethyl oxime
CAS No.:1202388-82-6
Molecular Formula:C₂₀H₂₄ClN₇O₂
Molecular Weight:429.909
Hs Code.:

Synonyms:1-(4-(5-chloro-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylamino)-2,5-dimethylphenyl)ethanone O-2-hydroxyethyl oxime

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Chemical Property of 1-(4-(5-chloro-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylamino)-2,5-dimethylphenyl)ethanone O-2-hydroxyethyl oxime

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Technology Process of 1-(4-(5-chloro-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylamino)-2,5-dimethylphenyl)ethanone O-2-hydroxyethyl oxime

There total 4 articles about 1-(4-(5-chloro-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylamino)-2,5-dimethylphenyl)ethanone O-2-hydroxyethyl oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3279-95-6
O-(2-hydroxyethyl)hydroxylamine

: 1202389-43-2
1-(4-(5-chloro-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylamino)-2,5-dimethylphenyl)ethanone

: 1202388-82-6
1-(4-(5-chloro-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylamino)-2,5-dimethylphenyl)ethanone O-2-hydroxyethyl oxime

Guidance literature:: With acetic acid; In methanol; at 60 ℃; for 14h;

Reference yield:

: 543712-81-8
2,5-dichloro-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine

: 1202388-82-6
1-(4-(5-chloro-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylamino)-2,5-dimethylphenyl)ethanone O-2-hydroxyethyl oxime

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / water; isopropyl alcohol / 1.67 h / 130 °C / microwave

2.1: toluene-4-sulfonic acid / tetrahydrofuran / 14 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 14 h / 100 °C / Inert atmosphere

3.2: 14 h

4.1: acetic acid / methanol / 14 h / 60 °C

With hydrogenchloride; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; water; isopropyl alcohol; toluene;

Reference yield:

: 1202389-41-0
N₂-(4-bromo-2,5-dimethylphenyl)-5-chloro-N₄-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

: 1202388-82-6
1-(4-(5-chloro-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylamino)-2,5-dimethylphenyl)ethanone O-2-hydroxyethyl oxime

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / tetrahydrofuran / 14 h / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 14 h / 100 °C / Inert atmosphere

2.2: 14 h

3.1: acetic acid / methanol / 14 h / 60 °C

With acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; toluene;