{(S)-1-[(S)-1-Ethyl-3-oxo-3-((1R,2R,4R)-1,7,7-trimethyl-2-trimethylsilanyloxy-bicyclo[2.2.1]hept-2-yl)-propylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:{(S)-1-[(S)-1-Ethyl-3-oxo-3-((1R,2R,4R)-1,7,7-trimethyl-2-trimethylsilanyloxy-bicyclo[2.2.1]hept-2-yl)-propylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester
CAS No.:450371-16-1
Molecular Formula:C₃₂H₅₂N₂O₅Si
Molecular Weight:572.861
Hs Code.:

{(S)-1-[(S)-1-Ethyl-3-oxo-3-((1R,2R,4R)-1,7,7-trimethyl-2-trimethylsilanyloxy-bicyclo[2.2.1]hept-2-yl)-propylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Synonyms:{(S)-1-[(S)-1-Ethyl-3-oxo-3-((1R,2R,4R)-1,7,7-trimethyl-2-trimethylsilanyloxy-bicyclo[2.2.1]hept-2-yl)-propylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

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Chemical Property of {(S)-1-[(S)-1-Ethyl-3-oxo-3-((1R,2R,4R)-1,7,7-trimethyl-2-trimethylsilanyloxy-bicyclo[2.2.1]hept-2-yl)-propylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

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Technology Process of {(S)-1-[(S)-1-Ethyl-3-oxo-3-((1R,2R,4R)-1,7,7-trimethyl-2-trimethylsilanyloxy-bicyclo[2.2.1]hept-2-yl)-propylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

There total 6 articles about {(S)-1-[(S)-1-Ethyl-3-oxo-3-((1R,2R,4R)-1,7,7-trimethyl-2-trimethylsilanyloxy-bicyclo[2.2.1]hept-2-yl)-propylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: (S)-3-Amino-1-((1R,2R,4R)-1,7,7-trimethyl-2-trimethylsilanyloxy-bicyclo[2.2.1]hept-2-yl)-pentan-1-one

: 450371-16-1
{(S)-1-[(S)-1-Ethyl-3-oxo-3-((1R,2R,4R)-1,7,7-trimethyl-2-trimethylsilanyloxy-bicyclo[2.2.1]hept-2-yl)-propylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 0 - 20 ℃; for 17h;
DOI:10.1021/ja026250s

Reference yield:

: 1075216-42-0
2-ethinyl-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol

: 450371-16-1
{(S)-1-[(S)-1-Ethyl-3-oxo-3-((1R,2R,4R)-1,7,7-trimethyl-2-trimethylsilanyloxy-bicyclo[2.2.1]hept-2-yl)-propylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid; mercury(II) oxide / water; acetone / 0.25 h / 60 °C

2: potassium hydride / tetrahydrofuran / 1 h / 20 °C

3: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.25 h / -78 °C

4: hydrogen / palladium on activated charcoal / ethyl acetate / 1 h / 20 °C

5: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 17 h / 0 - 20 °C

With sulfuric acid; hydrogen; potassium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; mercury(II) oxide; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; hexane; dichloromethane; water; ethyl acetate; acetone; 3: Mannich reaction;
DOI:10.1021/ja026250s

Reference yield:

: 204577-66-2
1-(2-hydroxy-1,7,7-trimethylbicyclo[2.2.1]hept-endo-2-yl)ethanone

: 450371-16-1
{(S)-1-[(S)-1-Ethyl-3-oxo-3-((1R,2R,4R)-1,7,7-trimethyl-2-trimethylsilanyloxy-bicyclo[2.2.1]hept-2-yl)-propylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hydride / tetrahydrofuran / 1 h / 20 °C

2: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.25 h / -78 °C

3: hydrogen / palladium on activated charcoal / ethyl acetate / 1 h / 20 °C

4: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 17 h / 0 - 20 °C

With hydrogen; potassium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; hexane; dichloromethane; ethyl acetate; 2: Mannich reaction;
DOI:10.1021/ja026250s