N-[[1-[3-chloro-5-(trifluoromethyl)-2-pyridyl]cyclopropyl]methyl]-2,6-difluoro-N-methoxy-benzamide

Base Information

Chemical Name:N-[[1-[3-chloro-5-(trifluoromethyl)-2-pyridyl]cyclopropyl]methyl]-2,6-difluoro-N-methoxy-benzamide
CAS No.:1433906-58-1
Molecular Formula:C₁₈H₁₄ClF₅N₂O₂
Molecular Weight:420.766
Hs Code.:

Synonyms:N-[[1-[3-chloro-5-(trifluoromethyl)-2-pyridyl]cyclopropyl]methyl]-2,6-difluoro-N-methoxy-benzamide

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Chemical Property of N-[[1-[3-chloro-5-(trifluoromethyl)-2-pyridyl]cyclopropyl]methyl]-2,6-difluoro-N-methoxy-benzamide

Chemical Property:

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Technology Process of N-[[1-[3-chloro-5-(trifluoromethyl)-2-pyridyl]cyclopropyl]methyl]-2,6-difluoro-N-methoxy-benzamide

There total 5 articles about N-[[1-[3-chloro-5-(trifluoromethyl)-2-pyridyl]cyclopropyl]methyl]-2,6-difluoro-N-methoxy-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1433906-84-3
3-chloro-2-[1-(iodomethyl)cyclopropyl]-5-(trifluoromethyl)pyridine

: 1433906-91-2
2,6-difluoro-N-methoxy-benzamide

: 1433906-58-1
N-[[1-[3-chloro-5-(trifluoromethyl)-2-pyridyl]cyclopropyl]methyl]-2,6-difluoro-N-methoxy-benzamide

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 70 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1433906-75-2
1-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-cyclopropanecarbonitrile

: 1433906-58-1
N-[[1-[3-chloro-5-(trifluoromethyl)-2-pyridyl]cyclopropyl]methyl]-2,6-difluoro-N-methoxy-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / 5 h / 20 °C / Reflux

2: diisopropyl aluminium hydride / toluene / 0.75 h / -78 - 20 °C / Inert atmosphere

3: triphenylphosphine; 1H-imidazole; iodine / dichloromethane / 20 °C / Cooling with ice

4: potassium carbonate / dimethyl sulfoxide / 1 h / 70 °C / Inert atmosphere

With 1H-imidazole; sulfuric acid; iodine; potassium carbonate; diisopropyl aluminium hydride; triphenylphosphine; In dichloromethane; dimethyl sulfoxide; toluene;

Reference yield:

: 1433906-82-1
methyl 1-[3-chloro-5-(trifluoromethyl)-2-pyridyl]cyclopropanecarboxylate

: 1433906-58-1
N-[[1-[3-chloro-5-(trifluoromethyl)-2-pyridyl]cyclopropyl]methyl]-2,6-difluoro-N-methoxy-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: diisopropyl aluminium hydride / toluene / 0.75 h / -78 - 20 °C / Inert atmosphere

2: triphenylphosphine; 1H-imidazole; iodine / dichloromethane / 20 °C / Cooling with ice

3: potassium carbonate / dimethyl sulfoxide / 1 h / 70 °C / Inert atmosphere

With 1H-imidazole; iodine; potassium carbonate; diisopropyl aluminium hydride; triphenylphosphine; In dichloromethane; dimethyl sulfoxide; toluene;