(+/-)-9-[(1-trityloxyethyl)(3-phosphonomethoxy)propyl]-N⁶-trityladenine

Base Information

Chemical Name:(+/-)-9-[(1-trityloxyethyl)(3-phosphonomethoxy)propyl]-N⁶-trityladenine
CAS No.:889886-13-9
Molecular Formula:C₄₉H₄₆N₅O₅P
Molecular Weight:815.908
Hs Code.:

(+/-)-9-[(1-trityloxyethyl)(3-phosphonomethoxy)propyl]-N<sup>6</sup>-trityladenine

Synonyms:(+/-)-9-[(1-trityloxyethyl)(3-phosphonomethoxy)propyl]-N⁶-trityladenine

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Chemical Property of (+/-)-9-[(1-trityloxyethyl)(3-phosphonomethoxy)propyl]-N⁶-trityladenine

Chemical Property:

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Technology Process of (+/-)-9-[(1-trityloxyethyl)(3-phosphonomethoxy)propyl]-N⁶-trityladenine

There total 9 articles about (+/-)-9-[(1-trityloxyethyl)(3-phosphonomethoxy)propyl]-N⁶-trityladenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 889886-10-6
(+/-)-9-[(1-trityloxyethyl)(3-hydroxy)propyl]-N⁶-trityladenine

: 35717-98-7
bis(2-propyl)-p-toluenesulfonyloxymethylphosphonate

: 889886-13-9
(+/-)-9-[(1-trityloxyethyl)(3-phosphonomethoxy)propyl]-N⁶-trityladenine

Guidance literature:: (+/-)-9-[(1-trityloxyethyl)(3-hydroxy)propyl]-N⁶-trityladenine; bis(2-propyl)-p-toluenesulfonyloxymethylphosphonate; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

With trimethylsilyl iodide; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 13h;
DOI:10.1080/15257770500265612

Reference yield:

: 889886-05-9
(+/-)-5-O-pivaloylpentane-1,3,5-triol

: 889886-13-9
(+/-)-9-[(1-trityloxyethyl)(3-phosphonomethoxy)propyl]-N⁶-trityladenine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 13 g / imidazole / CH₂Cl₂ / 1 h / 20 °C

2.1: 70 percent / Ph₃P; diethyl azodicarboxylate / dioxane / 19 h / 20 °C

3.1: 65 percent / NaOMe / methanol / 17 h / 20 °C

4.1: 54 percent / DMAP; pyridine; Et₃N / 17 h / Heating

5.1: 80 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 20 °C

6.1: NaH / dimethylformamide / 18 h / 20 °C

6.2: 0.15 g / Et₃N; TMSI / dimethylformamide / 13 h / 20 °C

With pyridine; 1H-imidazole; dmap; tetrabutyl ammonium fluoride; sodium methylate; sodium hydride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; 2.1: Mitsunobu reaction;
DOI:10.1080/15257770500265612

Reference yield:

: 889886-04-8
(+/-)-1-O-pivaloyl-3,5-O-isopropylidenepentane-1,3,5-triol

: 889886-13-9
(+/-)-9-[(1-trityloxyethyl)(3-phosphonomethoxy)propyl]-N⁶-trityladenine

Guidance literature:: Multi-step reaction with 7 steps

1.1: AcOH / H₂O / 15 h / 50 - 55 °C

2.1: 13 g / imidazole / CH₂Cl₂ / 1 h / 20 °C

3.1: 70 percent / Ph₃P; diethyl azodicarboxylate / dioxane / 19 h / 20 °C

4.1: 65 percent / NaOMe / methanol / 17 h / 20 °C

5.1: 54 percent / DMAP; pyridine; Et₃N / 17 h / Heating

6.1: 80 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 20 °C

7.1: NaH / dimethylformamide / 18 h / 20 °C

7.2: 0.15 g / Et₃N; TMSI / dimethylformamide / 13 h / 20 °C

With pyridine; 1H-imidazole; dmap; tetrabutyl ammonium fluoride; sodium methylate; sodium hydride; acetic acid; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; 3.1: Mitsunobu reaction;
DOI:10.1080/15257770500265612