(22R,23R,24R)-2α-benzyloxy-3α-palmitoyloxy-22,23-dihydroxy-24-methyl-B-homo-7-oxa-5α-cholestan-6-one

Base Information

Chemical Name:(22R,23R,24R)-2α-benzyloxy-3α-palmitoyloxy-22,23-dihydroxy-24-methyl-B-homo-7-oxa-5α-cholestan-6-one
CAS No.:1493793-31-9
Molecular Formula:C₅₁H₈₄O₇
Molecular Weight:809.224
Hs Code.:

Synonyms:(22R,23R,24R)-2α-benzyloxy-3α-palmitoyloxy-22,23-dihydroxy-24-methyl-B-homo-7-oxa-5α-cholestan-6-one

Suppliers and Price of (22R,23R,24R)-2α-benzyloxy-3α-palmitoyloxy-22,23-dihydroxy-24-methyl-B-homo-7-oxa-5α-cholestan-6-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (22R,23R,24R)-2α-benzyloxy-3α-palmitoyloxy-22,23-dihydroxy-24-methyl-B-homo-7-oxa-5α-cholestan-6-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (22R,23R,24R)-2α-benzyloxy-3α-palmitoyloxy-22,23-dihydroxy-24-methyl-B-homo-7-oxa-5α-cholestan-6-one

There total 10 articles about (22R,23R,24R)-2α-benzyloxy-3α-palmitoyloxy-22,23-dihydroxy-24-methyl-B-homo-7-oxa-5α-cholestan-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1493793-25-1
(22R,23R,24R)-2α-benzyloxy-3α-palmitoyloxy-22,23-dihydroxy-24-methyl-B-homo-7-oxa-5α-cholestan-6-one 22,23-methylboronate

: 1493793-31-9
(22R,23R,24R)-2α-benzyloxy-3α-palmitoyloxy-22,23-dihydroxy-24-methyl-B-homo-7-oxa-5α-cholestan-6-one

Guidance literature:: (22R,23R,24R)-2α-benzyloxy-3α-palmitoyloxy-22,23-dihydroxy-24-methyl-B-homo-7-oxa-5α-cholestan-6-one 22,23-methylboronate; With trimethylamine-N-oxide; In diethylene glycol dimethyl ether; for 0.75h; Reflux;

In ethanol;
DOI:10.1016/j.jsbmb.2013.01.016

Reference yield:

: 1493793-25-1
(22R,23R,24R)-2α-benzyloxy-3α-palmitoyloxy-22,23-dihydroxy-24-methyl-B-homo-7-oxa-5α-cholestan-6-one 22,23-methylboronate

: 1493793-31-9
(22R,23R,24R)-2α-benzyloxy-3α-palmitoyloxy-22,23-dihydroxy-24-methyl-B-homo-7-oxa-5α-cholestan-6-one

: 1493793-28-4
C₅₁H₈₃BO₈

Guidance literature:: With trimethylamine-N-oxide; In diethylene glycol dimethyl ether; for 0.75h; Overall yield = 56 mg; Reflux;
DOI:10.1016/j.jsbmb.2013.01.016

Reference yield:

: 1244967-00-7
(22R,23R,24R)-2α,3α,22,23-tetrahydroxy-24-methyl-B-homo-7-oxa-5α-cholestan-6-one 22,23-methylboronate

: 1493793-31-9
(22R,23R,24R)-2α-benzyloxy-3α-palmitoyloxy-22,23-dihydroxy-24-methyl-B-homo-7-oxa-5α-cholestan-6-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: silver(l) oxide / dichloromethane / 4 h / 20 °C

2.1: dicyclohexyl-carbodiimide / dichloromethane / 0.33 h / 20 °C

2.2: 48 h / 20 °C

3.1: trimethylamine-N-oxide / diethylene glycol dimethyl ether / 0.75 h / Reflux

3.2: Dowex-50W×8, 200–400 mesh, NH₄⁺ form resin

With trimethylamine-N-oxide; dicyclohexyl-carbodiimide; silver(l) oxide; In dichloromethane; diethylene glycol dimethyl ether;
DOI:10.1016/j.jsbmb.2013.01.016