1-[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-4-oxocyclohexanecarboxamide

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Chemical Name:1-[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-4-oxocyclohexanecarboxamide
CAS No.:1312536-83-6
Molecular Formula:C₂₂H₂₀F₃N₅O₂S
Molecular Weight:475.494
Hs Code.:

Synonyms:1-[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-4-oxocyclohexanecarboxamide

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Chemical Property of 1-[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-4-oxocyclohexanecarboxamide

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Technology Process of 1-[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-4-oxocyclohexanecarboxamide

There total 5 articles about 1-[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-4-oxocyclohexanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.6%

: 1312536-82-5
8-[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-1,4-dioxaspiro[4.5]decane-8-carboxamide

: 1312536-83-6
1-[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-4-oxocyclohexanecarboxamide

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; at 23 ℃; for 6h;

Reference yield:

: 69947-09-7
1,4-dioxaspiro<4.5>decane-8-carbonitrile

: 1312536-83-6
1-[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-4-oxocyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hexamethyldisilazane / toluene / 1 h / 0 °C

1.2: 16 h / 23 °C

2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 2 h / 50 °C

3.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane; water / 5 h / 100 °C

4.1: dihydrogen peroxide; potassium carbonate / dimethyl sulfoxide / 1.5 h / 70 °C

5.1: hydrogenchloride / tetrahydrofuran; water / 6 h / 23 °C

With hydrogenchloride; N-Bromosuccinimide; dihydrogen peroxide; sodium hexamethyldisilazane; potassium carbonate; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 3.1: Suzuki Coupling;

Reference yield:

8-(5-bromo-1,3-thiazol-2-yl)-1,4-dioxaspiro[4.5]decane-8-carbonitrile: 1312536-80-3
8-(5-bromo-1,3-thiazol-2-yl)-1,4-dioxaspiro[4.5]decane-8-carbonitrile

: 1312536-83-6
1-[5-(3-methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-4-oxocyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane; water / 5 h / 100 °C

2: dihydrogen peroxide; potassium carbonate / dimethyl sulfoxide / 1.5 h / 70 °C

3: hydrogenchloride / tetrahydrofuran; water / 6 h / 23 °C

With hydrogenchloride; dihydrogen peroxide; potassium carbonate; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide; 1: Suzuki Coupling;