2-[3-(N-biotinyl-6-aminohexanoyl)phenyl]-1,1-bis{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-1-butene

Base Information

Chemical Name:2-[3-(N-biotinyl-6-aminohexanoyl)phenyl]-1,1-bis{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-1-butene
CAS No.:1416136-85-0
Molecular Formula:C₅₀H₆₇N₅O₆S
Molecular Weight:866.178
Hs Code.:

Synonyms:2-[3-(N-biotinyl-6-aminohexanoyl)phenyl]-1,1-bis{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-1-butene

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Chemical Property of 2-[3-(N-biotinyl-6-aminohexanoyl)phenyl]-1,1-bis{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-1-butene

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Technology Process of 2-[3-(N-biotinyl-6-aminohexanoyl)phenyl]-1,1-bis{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-1-butene

There total 5 articles about 2-[3-(N-biotinyl-6-aminohexanoyl)phenyl]-1,1-bis{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-1-butene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1416136-84-9
2-(3-hydroxyphenyl)-1,1-bis{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-1-butene

: 72040-64-3
N-(+)-biotinyl-6-aminocaproic acid

: 1416136-85-0
2-[3-(N-biotinyl-6-aminohexanoyl)phenyl]-1,1-bis{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-1-butene

Guidance literature:: With dmap; 2-methyl-6-nitrobenzoic anhydride; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.10.037

Reference yield:

: 611-99-4
4,4'-Dihydroxybenzophenone

: 1416136-85-0
2-[3-(N-biotinyl-6-aminohexanoyl)phenyl]-1,1-bis{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-1-butene

Guidance literature:: Multi-step reaction with 4 steps

1.1: zinc; titanium tetrachloride; potassium carbonate / tetrahydrofuran / 2 h / 0 - 90 °C / Darkness; Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 0.25 h / 0 - 50 °C / Inert atmosphere

2.2: 3 h / 50 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 4.5 h / 20 °C / Inert atmosphere; Darkness

4.1: 2-methyl-6-nitrobenzoic anhydride; dmap; triethylamine / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C / Inert atmosphere

With dmap; palladium 10% on activated carbon; 2-methyl-6-nitrobenzoic anhydride; hydrogen; titanium tetrachloride; sodium hydride; potassium carbonate; triethylamine; zinc; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; paraffin oil;
DOI:10.1016/j.bmc.2012.10.037

Reference yield:

: 1416136-82-7
2-[3-(benzyloxy)phenyl]-1,1-bis(4-hydroxyphenyl)-1-butene

: 1416136-85-0
2-[3-(N-biotinyl-6-aminohexanoyl)phenyl]-1,1-bis{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-1-butene

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 0.25 h / 0 - 50 °C / Inert atmosphere

1.2: 3 h / 50 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 4.5 h / 20 °C / Inert atmosphere; Darkness

3.1: 2-methyl-6-nitrobenzoic anhydride; dmap; triethylamine / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C / Inert atmosphere

With dmap; palladium 10% on activated carbon; 2-methyl-6-nitrobenzoic anhydride; hydrogen; sodium hydride; triethylamine; In ethyl acetate; N,N-dimethyl-formamide; paraffin oil;
DOI:10.1016/j.bmc.2012.10.037