1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-N-[(1E)-1-(dimethylamino)ethylidene]-5-methyl-1H-pyrazole-3-carboxamide

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Chemical Name:1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-N-[(1E)-1-(dimethylamino)ethylidene]-5-methyl-1H-pyrazole-3-carboxamide
CAS No.:913572-06-2
Molecular Formula:C₂₃H₂₅ClN₄O₂
Molecular Weight:424.93
Hs Code.:

Synonyms:1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-N-[(1E)-1-(dimethylamino)ethylidene]-5-methyl-1H-pyrazole-3-carboxamide

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Chemical Property of 1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-N-[(1E)-1-(dimethylamino)ethylidene]-5-methyl-1H-pyrazole-3-carboxamide

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Technology Process of 1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-N-[(1E)-1-(dimethylamino)ethylidene]-5-methyl-1H-pyrazole-3-carboxamide

There total 5 articles about 1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-N-[(1E)-1-(dimethylamino)ethylidene]-5-methyl-1H-pyrazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 913572-01-7
1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazole-3-carboxamide

: 18871-66-4
N,N-dimethylacetamide dimethyl acetal

: 913572-06-2
1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-N-[(1E)-1-(dimethylamino)ethylidene]-5-methyl-1H-pyrazole-3-carboxamide

Guidance literature:: for 2h; Heating / reflux;

Reference yield:

: 851205-62-4
1-(5-chloro-2-hydroxybenzyl)-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

: 913572-06-2
1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-N-[(1E)-1-(dimethylamino)ethylidene]-5-methyl-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 18 h / Heating / reflux

2: sodium hydroxide; ethanol; water / 0.5 h / Heating / reflux

3: 4-methyl-morpholine; N-hydroxybenzotriazole ammonium salt; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

4: 2 h / Heating / reflux

With 4-methyl-morpholine; sodium hydroxide; N-hydroxybenzotriazole ammonium salt; ethanol; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; acetone;

Reference yield:

: 851204-79-0
1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazole-3-carboxylic acid

: 913572-06-2
1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-N-[(1E)-1-(dimethylamino)ethylidene]-5-methyl-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 4-methyl-morpholine; N-hydroxybenzotriazole ammonium salt; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

2: 2 h / Heating / reflux

With 4-methyl-morpholine; N-hydroxybenzotriazole ammonium salt; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;