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Technology Process of H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH

H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH

Base Information
  • Chemical Name:H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH
  • CAS No.:249537-73-3
  • Molecular Formula:C75H118 N20 O22 S
  • Molecular Weight:1683.93
  • Hs Code.:2933299090
  • Mol file:249537-73-3.mol
H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH

Synonyms:109:PN: US20040002117 FIGURE: 4D unclaimed protein; 13: PN: WO2007074198 SEQID: 13unclaimed sequence; 1: PN: WO2008156363 PAGE: 12 claimed protein; 1: PN:WO2009054361 SEQID: 1 claimed sequence; 29: PN: WO2006064072 SEQID: 39unclaimed sequence; 2: PN: WO2008156363 PAGE: 12 claimed protein; 42: PN:US6844324 SEQID: 42 claimed sequence; Peptide VIVIT (synthetic NFAT inhibitory)

Suppliers and Price of H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • NFAT Inhibitor
  • 1mg
  • $ 516.00
  • Tocris
  • NFAT Inhibitor
  • 1
  • $ 233.00
  • Sigma-Aldrich
  • NFAT Inhibitor >96% (HPLC), solid
  • 0.5 mg
  • $ 420.00
  • Sigma-Aldrich
  • NFAT Inhibitor >96% (HPLC), solid
  • .5mg
  • $ 405.00
  • DC Chemicals
  • NFAT Inhibitor >98%
  • 100 mg
  • $ 850.00
  • DC Chemicals
  • NFAT Inhibitor >98%
  • 1 g
  • $ 2700.00
  • Cayman Chemical
  • NFAT Inhibitor ≥95%
  • 5mg
  • $ 321.00
  • Cayman Chemical
  • NFAT Inhibitor ≥95%
  • 1mg
  • $ 72.00
  • Cayman Chemical
  • NFAT Inhibitor ≥95%
  • 10mg
  • $ 571.00
  • Biorbyt Ltd
  • NFAT inhibitor >98%
  • 1 g
  • $ 4023.90
Total 23 raw suppliers
Chemical Property of H-MET-ALA-GLY-PRO-HIS-PRO-VAL-ILE-VAL-ILE-THR-GLY-PRO-HIS-GLU-GLU-OH
Chemical Property:
  • Boiling Point:1982.4±65.0 °C(Predicted) 
  • PKA:3.12±0.10(Predicted) 
  • PSA：650.94000 
  • Density:1.334±0.06 g/cm3(Predicted) 
  • LogP:0.87570 
  • Storage Temp.:−20°C 
Purity/Quality:

97% *data from raw suppliers

NFAT Inhibitor *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
  • Safety Statements: 22-24/25 
MSDS Files:

SDS file from LookChem

Useful:
  • Description NFAT inhibitor is a cell-permeable compound that selectively inhibits calcineurin-mediated dephosphorylation of NFAT. At 100 μM, this inhibitor effectively blocks calcineurin binding to NFAT without disrupting other calcineurin-dependent pathways, unlike the immunosuppressants cyclosporin A and FK506 which indiscriminately block all calcineurin phosphatase activity. NFAT inhibitor can disrupt NFAT-dependent expression of IL-2 and TNF-α when transfected in Jurak T cells and can prevent the activation and proliferation of T cells both in vitro (~ 43% at 1 μM using mixed lymphocyte cultures) and in vivo (10 mg/kg using C3H/HeN mice).
  • Uses NFAT Inhibitor, VIVIT has been used to study the signaling pathways involved in controlling inhibitory molecules and subsequent onset of T-cell impairment.
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