Z-ALA-ALA-LEU-PNA

Base Information

• Chemical Name: Z-ALA-ALA-LEU-PNA
• CAS No.: 61043-33-2
• Molecular Formula: C26H33 N5 O7
• Molecular Weight: 527.577
• Mol file: 61043-33-2.mol

Synonyms:Benzyloxycarbonyl-L-alanyl-L-alanyl-L-leucyl-p-nitroanilide;N-Benzyloxycarbonyl-L-alanyl-L-alanyl-L-leucine-p-nitroanilide;Z-Ala-Ala-Leu-p-nitroanilide

Chemical Property of Z-ALA-ALA-LEU-PNA

Chemical Property:

• PSA: 171.45000
• LogP: 4.65270
• Storage Temp.: -15°C

Purity/Quality:

99% ^*data from raw suppliers

Z-Ala-Ala-Leu-pNA,99% 99% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-ALA-ALA-LEU-PNA

There total 3 articles about Z-ALA-ALA-LEU-PNA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

N-[(benzyloxy)carbonyl]-L-alanyl-L-alanine methyl ester (2483-51-4) + (S)-2-amino-4-methyl-N-(4-nitrophenyl)valeramide (4178-93-2,110893-28-2,86237-92-5,63324-49-2,6664-98-8) → Z-Ala-Ala-Leu-pNA (61043-33-2)

Guidance literature:

With Bacillus subtilis strain 72 serine protease; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃; for 2h;

DOI:10.1007/s11171-005-0072-y

Reference yield: 91.0%

benzyloxycarbonyl-L-alanyl-L-alanine (16012-70-7) + (S)-2-amino-4-methyl-N-(4-nitrophenyl)valeramide (4178-93-2,110893-28-2,86237-92-5,63324-49-2,6664-98-8) → Z-Ala-Ala-Leu-pNA (61043-33-2)

Guidance literature:

With Tris-HCl buffer; calcium chloride; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃; for 24h; pH=7.2;

DOI:10.1134/S1068162008040079

Reference yield:

→ Z-Ala-Ala-Leu-pNA (61043-33-2)

Guidance literature:

DOI:10.1111/j.1432-1033.1976.tb10852.x

upstream raw materials:

N-[(benzyloxy)carbonyl]-L-alanyl-L-alanine methyl ester

(S)-2-amino-4-methyl-N-(4-nitrophenyl)valeramide

benzyloxycarbonyl-L-alanyl-L-alanine

Downstream raw materials:

N-benzyloxycarbonyl-alanyl-alanyl-leucine

4-nitro-aniline

Refernces

• 1、 Filippova,Bacheva,Baibak,Plieva,Lysogorskaya,Oksenoit,Lozinsky. "Proteinases immobilized on poly(vinyl alcohol) cryogel: Novel biocatalysts for peptide synthesis in organic media". . p. 1896 - 1901. Retrieved 2001.
• 2、 Filippova,Lysogorskaya. "Modified Proteases for Peptide Synthesis in Organic Media". . p. 496 - 501. Retrieved 2003.