(R,S)-Boc-3-amino-3-(4-bromophenyl)-propionic acid

Base Information

• Chemical Name: (R,S)-Boc-3-amino-3-(4-bromophenyl)-propionic acid
• CAS No.: 282524-86-1
• Molecular Formula: C14H18BrNO4
• Molecular Weight: 344.205
• Hs Code.: 29225090
• Mol file: 282524-86-1.mol

Synonyms:3-(4-Bromophenyl)-3-[(tert-butoxycarbonyl)amino]propanoic acid;3-(4-Bromo-phenyl)-3-tert-butoxycarbonylamino-propionic acid;

Chemical Property of (R,S)-Boc-3-amino-3-(4-bromophenyl)-propionic acid

Chemical Property:

• Melting Point: 195-196°
• Boiling Point: 479.1 °C at 760 mmHg
• Flash Point: 243.6 °C
• PSA: 75.63000
• Density: 1.403 g/cm³
• LogP: 3.88050
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

3-(4-Bromophenyl)-3-[(tert-butoxycarbonyl)amino]propanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R,S)-Boc-3-amino-3-(4-bromophenyl)-propionic acid

There total 1 articles about (R,S)-Boc-3-amino-3-(4-bromophenyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.99%

di-tert-butyl dicarbonate (24424-99-5) + 3-amino-3-(4'-bromophenyl)propanoic acid (39773-47-2,295356-30-8) → 3-(4-bromophenyl)-3-((tert-butoxycarbonyl)amino)propionic acid (282524-86-1,261165-06-4)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 12h;

Reference yield:

3-(4-bromophenyl)-3-((tert-butoxycarbonyl)amino)propionic acid (282524-86-1,261165-06-4) → C14H17BrNO4Pol

Guidance literature:

With dmap; diisopropyl-carbodiimide; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 12h; Polystyrene A OH (Rapp, No. HA 1 400 00)

Reference yield:

3-(4-bromophenyl)-3-((tert-butoxycarbonyl)amino)propionic acid (282524-86-1,261165-06-4) → C35H36N2O6

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; methanesulfonyl chloride / Inert atmosphere

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate / N,N-dimethyl-formamide / Inert atmosphere

With dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate; methanesulfonyl chloride; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2010.11.116

upstream raw materials:

di-tert-butyl dicarbonate

3-amino-3-(4'-bromophenyl)propanoic acid

Downstream raw materials:

C₂₂H₂₀N₂O₄

Refernces

• 1、 -. "Dihydropyridine compound and application thereof to drugs". Paragraph 0664-0666. . Retrieved 2019/05/08.