((Bis((1,1-dimethylethoxy)carbonyl)amino)oxy)acetic acid

Base Information

• Chemical Name: ((Bis((1,1-dimethylethoxy)carbonyl)amino)oxy)acetic acid
• CAS No.: 293302-31-5
• Molecular Formula: C₁₂H₂₁NO₇
• Molecular Weight: 291.301
• Hs Code.: 29225090
• DSSTox Substance ID: DTXSID70373172
• Mol file: 293302-31-5.mol

Synonyms:293302-31-5;BIS-BOC-AMINO-OXYACETIC ACID;Bis-Boc-Aoa;((Bis((1,1-dimethylethoxy)carbonyl)amino)oxy)acetic acid;2-[bis[(2-methylpropan-2-yl)oxycarbonyl]amino]oxyacetic Acid;Bis-boc-aoa h2o;Bis-Boc-aminooxyacetic acid;2-({bis[(tert-butoxy)carbonyl]amino}oxy)acetic acid;[[Bis[(1,1-dimethylethoxy)carbonyl]amino]oxy]acetic acid;{[bis(tert-butoxycarbonyl)amino]oxy}acetic acid;bis(boc)amino-oxyacetic acid;SCHEMBL2386657;DTXSID70373172;([Bis-Boc-Amino]oxy)acetic acid;2-[(Bis-Boc)amino]oxyacetic acid;MFCD06410966;AKOS015901093;GS-6543;BOC-AOA-OH Bis-Boc-aMinooxyacetic acid;Bis-Boc-AOA-OH Bis-Boc-aminooxyacetic acid;CS-0154826;FT-0679713;2-(bis(tert-butoxycarbonyl)aminooxy)acetic acid;H10387;A850858;J-017474;J-519903;Acetic acid, 2-[[bis[(1,1-dimethylethoxy)carbonyl]amino]oxy]-

Chemical Property of ((Bis((1,1-dimethylethoxy)carbonyl)amino)oxy)acetic acid

Chemical Property:

• Boiling Point: 360.0±44.0 °C(Predicted)
• PKA: 2.65±0.10(Predicted)
• PSA: 102.37000
• Density: 1.204±0.06 g/cm3(Predicted)
• LogP: 2.17480
• Storage Temp.: Store at 0-5°C
• Water Solubility.: Slightly soluble in water.
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 7
• Exact Mass: 291.13180201
• Heavy Atom Count: 20
• Complexity: 350

Purity/Quality:

98%,99%, ^*data from raw suppliers

Bis-Boc-Aoa ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)OCC(=O)O

Technology Process of ((Bis((1,1-dimethylethoxy)carbonyl)amino)oxy)acetic acid

There total 1 articles about ((Bis((1,1-dimethylethoxy)carbonyl)amino)oxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C19H27NO7 (293302-30-4) → ((bis-(tert-butoxycarbonyl)amino)oxy)acetic acid (293302-31-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃;

DOI:10.1039/c0ob00133c

Reference yield: 85.9%

Glu(Val-Cit-PAB-SN-38)-PEG12u + ((bis-(tert-butoxycarbonyl)amino)oxy)acetic acid (293302-31-5) → (Boc)2N-OCH2CO-Glu(Val-Cit-PAB-SN-38)-PEG12u

Guidance literature:

With 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h; Cooling with ice;

Reference yield: 83.3%

Glu(Val-Cit-PAB-SN-38)-PEG24u + ((bis-(tert-butoxycarbonyl)amino)oxy)acetic acid (293302-31-5) → (Boc)2N-OCH2CO-Glu(Val-Cit-PAB-SN-38)-PEG24u

Guidance literature:

With 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h; Cooling with ice;

upstream raw materials:

C₁₉H₂₇NO₇

Refernces