6-(4-chlorobutyl)-4-(phenylthio)-1-tosyl-1,6-dihydropyridin-2(3H)-one

Base Information

• Chemical Name: 6-(4-chlorobutyl)-4-(phenylthio)-1-tosyl-1,6-dihydropyridin-2(3H)-one
• CAS No.: 1301264-22-1
• Molecular Formula: C₂₂H₂₄ClNO₃S₂
• Molecular Weight: 450.022

Synonyms:6-(4-chlorobutyl)-4-(phenylthio)-1-tosyl-1,6-dihydropyridin-2(3H)-one

Chemical Property of 6-(4-chlorobutyl)-4-(phenylthio)-1-tosyl-1,6-dihydropyridin-2(3H)-one

Chemical Property:

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Technology Process of 6-(4-chlorobutyl)-4-(phenylthio)-1-tosyl-1,6-dihydropyridin-2(3H)-one

There total 1 articles about 6-(4-chlorobutyl)-4-(phenylthio)-1-tosyl-1,6-dihydropyridin-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-thiophenyl-3-sulfolene (64741-13-5) → 6-(4-chlorobutyl)-4-(phenylthio)-1-tosyl-1,6-dihydropyridin-2(3H)-one (1301264-22-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide / -78 °C

1.2: -78 - -50 °C

2.1: sodium hydrogencarbonate; hydroquinone / toluene / 6 h / Inert atmosphere; Reflux

With n-butyllithium; sodium hydrogencarbonate; hydroquinone; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; toluene;

DOI:10.1055/s-0030-1258415

Reference yield: 96.0%

6-(4-chlorobutyl)-4-(phenylthio)-1-tosyl-1,6-dihydropyridin-2(3H)-one (1301264-22-1) → trans-5-bromo-6-(4-chlorobutyl)-4-(phenylthio)-1-tosyl-5,6-dihydropyridin-2(1H)-one

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; for 2h; Inert atmosphere; Reflux;

DOI:10.1055/s-0030-1258415

Reference yield:

6-(4-chlorobutyl)-4-(phenylthio)-1-tosyl-1,6-dihydropyridin-2(3H)-one (1301264-22-1) → trans-6-(4-chlorobutyl)-5-hydroxy-4-(phenylthio)-5,6-dihydropyridin-2(1H)-one

Guidance literature:

Multi-step reaction with 3 steps

1: N-Bromosuccinimide / acetonitrile / 2 h / Inert atmosphere; Reflux

2: water; triethylamine / acetonitrile / 24 h / 70 °C / Inert atmosphere

3: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 1 h / Reflux

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); water; tri-n-butyl-tin hydride; triethylamine; In toluene; acetonitrile;

DOI:10.1055/s-0030-1258415

upstream raw materials:

3-thiophenyl-3-sulfolene

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