4-(3-tertbutylphenoxy)-5-trifluoromethyl-2-methylnitrobenzene

Base Information

• Chemical Name: 4-(3-tertbutylphenoxy)-5-trifluoromethyl-2-methylnitrobenzene
• CAS No.: 1054538-47-4
• Molecular Formula: C₁₈H₁₈F₃NO₃
• Molecular Weight: 353.341
• Mol file: 1054538-47-4.mol

Synonyms:4-(3-tertbutylphenoxy)-5-trifluoromethyl-2-methylnitrobenzene

Chemical Property of 4-(3-tertbutylphenoxy)-5-trifluoromethyl-2-methylnitrobenzene

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-(3-tertbutylphenoxy)-5-trifluoromethyl-2-methylnitrobenzene

There total 2 articles about 4-(3-tertbutylphenoxy)-5-trifluoromethyl-2-methylnitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

3-tert-butylphenyol (585-34-2) + 1-chloro-5-methyl-4-nitro-2-(trifluoromethyl)benzene (873006-35-0) → 4-(3-tertbutylphenoxy)-5-trifluoromethyl-2-methylnitrobenzene (1054538-47-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 0.25h;

Reference yield:

2-chloro-4-methyl-1-trifluoromethylbenzene (74483-46-8) → 4-(3-tertbutylphenoxy)-5-trifluoromethyl-2-methylnitrobenzene (1054538-47-4)

Guidance literature:

Multi-step reaction with 2 steps

1: nitric acid / sulfuric acid / sulfuric acid / 0.25 h / 0 °C

2: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 50 °C

With nitric acid; potassium carbonate; sulfuric acid; In sulfuric acid; N,N-dimethyl-formamide;

Reference yield: 63.5%

4-(3-tertbutylphenoxy)-5-trifluoromethyl-2-methylnitrobenzene (1054538-47-4) → 4-(3-tertbutylphenoxy)-5-trifluoromethyl-2-methylaniline (1054538-45-2)

Guidance literature:

With hydrogenchloride; tin(II) chloride dihdyrate; In methanol; for 4h; Cooling with ice; Reflux;

upstream raw materials:

3-tert-butylphenyol

1-chloro-5-methyl-4-nitro-2-(trifluoromethyl)benzene

2-chloro-4-methyl-1-trifluoromethylbenzene

Downstream raw materials:

4-(3-tertbutylphenoxy)-5-trifluoromethyl-2-methylaniline