(2S,3R,4R)-4-((4R,5R,6R)-5-Benzyloxy-2,2,6-trimethyl-[1,3]dioxan-4-yl)-2,3-bis-(2-trimethylsilanyl-ethoxymethoxy)-pentanoic acid methyl ester

Base Information

Chemical Name:(2S,3R,4R)-4-((4R,5R,6R)-5-Benzyloxy-2,2,6-trimethyl-[1,3]dioxan-4-yl)-2,3-bis-(2-trimethylsilanyl-ethoxymethoxy)-pentanoic acid methyl ester
CAS No.:194934-60-6
Molecular Formula:C₃₂H₅₈O₉Si₂
Molecular Weight:642.978
Hs Code.:

Synonyms:(2S,3R,4R)-4-((4R,5R,6R)-5-Benzyloxy-2,2,6-trimethyl-[1,3]dioxan-4-yl)-2,3-bis-(2-trimethylsilanyl-ethoxymethoxy)-pentanoic acid methyl ester

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Chemical Property of (2S,3R,4R)-4-((4R,5R,6R)-5-Benzyloxy-2,2,6-trimethyl-[1,3]dioxan-4-yl)-2,3-bis-(2-trimethylsilanyl-ethoxymethoxy)-pentanoic acid methyl ester

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Technology Process of (2S,3R,4R)-4-((4R,5R,6R)-5-Benzyloxy-2,2,6-trimethyl-[1,3]dioxan-4-yl)-2,3-bis-(2-trimethylsilanyl-ethoxymethoxy)-pentanoic acid methyl ester

There total 8 articles about (2S,3R,4R)-4-((4R,5R,6R)-5-Benzyloxy-2,2,6-trimethyl-[1,3]dioxan-4-yl)-2,3-bis-(2-trimethylsilanyl-ethoxymethoxy)-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 194934-59-3
methyl (2S,3R,4R)-4-[5-(R)-benzyloxy-2,2,6-(6R)-trimethyl-1,3-dioxan-4-(R)-yl]-2,3-dihydroxy-pentanoate

: 194934-60-6
(2S,3R,4R)-4-((4R,5R,6R)-5-Benzyloxy-2,2,6-trimethyl-[1,3]dioxan-4-yl)-2,3-bis-(2-trimethylsilanyl-ethoxymethoxy)-pentanoic acid methyl ester

Guidance literature:: With dichloromethane; i-Pr₂Et; In dichloromethane; at 40 ℃; for 24h;
DOI:10.1016/S0040-4039(97)01257-4

Reference yield:

: 194934-58-2
(S)-2-[5-(R)-benzyloxy-2,2,6-(6R)-trimethyl-1,3-dioxan-4-(R)-yl]-propionaldehyde

: 194934-60-6
(2S,3R,4R)-4-((4R,5R,6R)-5-Benzyloxy-2,2,6-trimethyl-[1,3]dioxan-4-yl)-2,3-bis-(2-trimethylsilanyl-ethoxymethoxy)-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / i-Pr₂NEt, LiCl / acetonitrile / 17 h / 20 °C

2: 98 percent / AD-mix-β<(DHQD)2PHAL>, K2OsO2(OH)4, K3Fe(CN)6, K2CO3, MeSO2NH2 / 2-methyl-propan-2-ol; H2O / 17 h / 20 °C

3: 97 percent / i-Pr₂Et, CH₂Cl₂ / CH₂Cl₂ / 24 h / 40 °C

With potassium dioxotetrahydroxoosmate(VI); dichloromethane; methanesulfonamide; i-Pr₂Et; potassium carbonate; 1,4-bis(9-O-dihydroquinidine)phthalazine; N-ethyl-N,N-diisopropylamine; lithium chloride; potassium hexacyanoferrate(III); In dichloromethane; water; acetonitrile; tert-butyl alcohol;
DOI:10.1016/S0040-4039(97)01257-4

Reference yield:

: 862509-84-0
(4R,5R,6R)-5-benzyloxy-4-[1-hydroxy-prop-2-(R)-yl]-2,2,6-trimethyl-1,3-dioxane

: 194934-60-6
(2S,3R,4R)-4-((4R,5R,6R)-5-Benzyloxy-2,2,6-trimethyl-[1,3]dioxan-4-yl)-2,3-bis-(2-trimethylsilanyl-ethoxymethoxy)-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 1 h, 2.) CH₂Cl₂, -25 deg C, 1 h

2: 88 percent / i-Pr₂NEt, LiCl / acetonitrile / 17 h / 20 °C

3: 98 percent / AD-mix-β<(DHQD)2PHAL>, K2OsO2(OH)4, K3Fe(CN)6, K2CO3, MeSO2NH2 / 2-methyl-propan-2-ol; H2O / 17 h / 20 °C

4: 97 percent / i-Pr₂Et, CH₂Cl₂ / CH₂Cl₂ / 24 h / 40 °C

With oxalyl dichloride; potassium dioxotetrahydroxoosmate(VI); dichloromethane; methanesulfonamide; i-Pr₂Et; potassium carbonate; dimethyl sulfoxide; 1,4-bis(9-O-dihydroquinidine)phthalazine; triethylamine; N-ethyl-N,N-diisopropylamine; lithium chloride; potassium hexacyanoferrate(III); In dichloromethane; water; acetonitrile; tert-butyl alcohol;
DOI:10.1016/S0040-4039(97)01257-4