3-{4-[2-(4-bromo-2-chlorophenoxy)-2-methylpropionylamino]phenyl}hex-4-ynoic acid

Base Information

Chemical Name:3-{4-[2-(4-bromo-2-chlorophenoxy)-2-methylpropionylamino]phenyl}hex-4-ynoic acid
CAS No.:1354048-20-6
Molecular Formula:C₂₂H₂₁BrClNO₄
Molecular Weight:478.77
Hs Code.:

Synonyms:3-{4-[2-(4-bromo-2-chlorophenoxy)-2-methylpropionylamino]phenyl}hex-4-ynoic acid

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Chemical Property of 3-{4-[2-(4-bromo-2-chlorophenoxy)-2-methylpropionylamino]phenyl}hex-4-ynoic acid

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Technology Process of 3-{4-[2-(4-bromo-2-chlorophenoxy)-2-methylpropionylamino]phenyl}hex-4-ynoic acid

There total 4 articles about 3-{4-[2-(4-bromo-2-chlorophenoxy)-2-methylpropionylamino]phenyl}hex-4-ynoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1354048-28-4
2-(1-{4-[2-(4-Bromo-2-chlorophenoxy)-2-methylpropionylamino]phenyl}but-2-ynyl)-malonic Acid

: 1354048-20-6
3-{4-[2-(4-bromo-2-chlorophenoxy)-2-methylpropionylamino]phenyl}hex-4-ynoic acid

Guidance literature:: In 1,4-dioxane; at 120 ℃; for 17h;

Reference yield:

: 865233-58-5
2-[1-(4-amino-phenyl)-but-2-ynyl]-malonic acid dimethyl ester

: 1354048-20-6
3-{4-[2-(4-bromo-2-chlorophenoxy)-2-methylpropionylamino]phenyl}hex-4-ynoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethylmorpholine; / N,N-dimethyl-formamide / 90 h / 20 °C

2.1: sodium hydroxide; water / acetonitrile / 18 h / 20 °C

2.2: pH 1

3.1: 1,4-dioxane / 17 h / 120 °C

With N-ethylmorpholine;; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1354048-27-3
Dimethyl 2-(1-{4-[2-(4-bromo-2-chlorophenoxy)-2-methylpropionylamino]phenyl}but-2-ynyl)malonate

: 1354048-20-6
3-{4-[2-(4-bromo-2-chlorophenoxy)-2-methylpropionylamino]phenyl}hex-4-ynoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / acetonitrile / 18 h / 20 °C

1.2: pH 1

2.1: 1,4-dioxane / 17 h / 120 °C

With water; sodium hydroxide; In 1,4-dioxane; acetonitrile;