2-<2-bromo-5-(valerylamino)phenyl>-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2,4-dihydro-5-ethyl-3H-1,2,4-triazol-3-one

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Chemical Name:2-<2-bromo-5-(valerylamino)phenyl>-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2,4-dihydro-5-ethyl-3H-1,2,4-triazol-3-one
CAS No.:168473-49-2
Molecular Formula:C₃₂H₃₇BrFN₅O₄S
Molecular Weight:686.645
Hs Code.:

Synonyms:2-<2-bromo-5-(valerylamino)phenyl>-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2,4-dihydro-5-ethyl-3H-1,2,4-triazol-3-one

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Chemical Property of 2-<2-bromo-5-(valerylamino)phenyl>-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2,4-dihydro-5-ethyl-3H-1,2,4-triazol-3-one

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Technology Process of 2-<2-bromo-5-(valerylamino)phenyl>-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2,4-dihydro-5-ethyl-3H-1,2,4-triazol-3-one

There total 6 articles about 2-<2-bromo-5-(valerylamino)phenyl>-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2,4-dihydro-5-ethyl-3H-1,2,4-triazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 638-29-9
n-valeryl chloride

: 168473-48-1
2-(5-amino-2-bromophenyl)-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2,4-dihydro-5-ethyl-3H-1,2,4-triazol-3-one

: 168473-49-2
2-<2-bromo-5-(valerylamino)phenyl>-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2,4-dihydro-5-ethyl-3H-1,2,4-triazol-3-one

Guidance literature:: With dmap; In pyridine; Ambient temperature;
DOI:10.1021/jm00019a004

Reference yield:

: 51436-99-8
2-fluoro-4-bromotoluene

: 168473-49-2
2-<2-bromo-5-(valerylamino)phenyl>-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2,4-dihydro-5-ethyl-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / aq. NaOH, tetrakis(triphenylphosphine)palladium⁽⁰⁾ / ethanol / 4.5 h / 90 °C

2: Br₂ / CCl₄ / Heating; Irradiation

3: 1.) NaH / 1.) DMF, 50 deg C, 3 h, 2.) DMF, 50 deg C, 3 h

4: 213 mg / SnCl₂, conc. HCl / tetrahydrofuran / 6 h / Ambient temperature

5: 44 percent / DMAP / pyridine / Ambient temperature

With hydrogenchloride; dmap; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; sodium hydride; tin(ll) chloride; In tetrahydrofuran; pyridine; tetrachloromethane; ethanol;
DOI:10.1021/jm00019a004

Reference yield:

: 150691-04-6
2-(tert-butylamino)sulfonylphenylboronic acid

: 168473-49-2
2-<2-bromo-5-(valerylamino)phenyl>-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2,4-dihydro-5-ethyl-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / aq. NaOH, tetrakis(triphenylphosphine)palladium⁽⁰⁾ / ethanol / 4.5 h / 90 °C

2: Br₂ / CCl₄ / Heating; Irradiation

3: 1.) NaH / 1.) DMF, 50 deg C, 3 h, 2.) DMF, 50 deg C, 3 h

4: 213 mg / SnCl₂, conc. HCl / tetrahydrofuran / 6 h / Ambient temperature

5: 44 percent / DMAP / pyridine / Ambient temperature

With hydrogenchloride; dmap; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; sodium hydride; tin(ll) chloride; In tetrahydrofuran; pyridine; tetrachloromethane; ethanol;
DOI:10.1021/jm00019a004