Fmoc-N-(2,4-dimethoxybenzyl)-Gly-OH

Base Information

• Chemical Name: Fmoc-N-(2,4-dimethoxybenzyl)-Gly-OH
• CAS No.: 166881-42-1
• Molecular Formula: C26H25 N O6
• Molecular Weight: 447.488
• Hs Code.: 29242990
• European Community (EC) Number: 623-771-0
• DSSTox Substance ID: DTXSID90444217
• Nikkaji Number: J808.628A
• Wikidata: Q82262285
• Mol file: 166881-42-1.mol

Synonyms:Fmoc-(Dmb)Gly-OH;166881-42-1;Fmoc-N-(2,4-dimethoxybenzyl)-Gly-OH;Fmoc-Gly(Dmb)-OH;2-[(2,4-dimethoxyphenyl)methyl-(9H-fluoren-9-ylmethoxycarbonyl)amino]acetic Acid;N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N-(2,4-dimethoxybenzyl)glycine;Glycine, N-[(2,4-dimethoxyphenyl)methyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-;Fmoc-DmbGly-OH;Fmoc-Dmb-Gly-OH;Fmoc-N-(2,4-dimethoxybenzyl)glycine;DTXSID90444217;AMY22819;EX-A3848;MFCD08064316;AKOS015911836;FD21648;GS-6398;HY-W047794;N-Fmoc-N-(2,4-Dimethoxybenzyl)-Gly-OH;PD197177;CS-0099800;A903547;J-010313;Fmoc-N-(2,4-dimethoxybenzyl)-Gly-OH, >=98.0% (HPLC);2-{[(2,4-dimethoxyphenyl)methyl]({[(9H-fluoren-9-yl)methoxy]carbonyl})amino}acetic acid;FMoc-N-(2,4-diMethoxybenzyl)-glycine;N-(((9H-fluoren-9-yl)methoxy)carbonyl)-N-(2,4-dimethoxybenzyl)glycine

Chemical Property of Fmoc-N-(2,4-dimethoxybenzyl)-Gly-OH

Chemical Property:

• Boiling Point: 653.2±55.0 °C(Predicted)
• PKA: 3.81±0.10(Predicted)
• PSA: 85.30000
• Density: 1.280±0.06 g/cm3(Predicted)
• LogP: 4.53950
• Storage Temp.: Store at 0°C
• XLogP3: 4.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 9
• Exact Mass: 447.16818752
• Heavy Atom Count: 33
• Complexity: 649

Purity/Quality:

97% ^*data from raw suppliers

Fmoc-N-(2,4-dimethoxybenzyl)-Gly-OH ≥98.0% (HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)CN(CC(=O)O)C(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)OC

Technology Process of Fmoc-N-(2,4-dimethoxybenzyl)-Gly-OH

There total 3 articles about Fmoc-N-(2,4-dimethoxybenzyl)-Gly-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-Dimethoxybenzaldehyde (613-45-6) → 2-((((9H-fluoren-9-yl)methoxy)carbonyl)(2,4-dimethoxybenzyl)amino)acetic acid (166881-42-1)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 17 h

2: sodium hydroxide / 1,4-dioxane / 1 h

3: 1,4-dioxane / 0.5 h

With sodium tris(acetoxy)borohydride; triethylamine; sodium hydroxide; In 1,4-dioxane; 1,2-dichloro-ethane;

DOI:10.1039/c3ob42238k

Reference yield:

(2,4-dimethoxy-benzylamino)-acetic acid (20839-79-6) + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → Fmoc-(Dmb)Gly-OH; Dmb = 2,4-dimethoxybenzyl (166881-42-1)

Guidance literature:

(2,4-dimethoxy-benzylamino)-acetic acid; With N,O-bis-(trimethylsilyl)-acetamide; In dichloromethane;

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide; With N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1016/j.tetlet.2006.04.074

Reference yield:

(2,4-dimethoxy-benzylamino)-acetic acid (20839-79-6) + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → 2-((((9H-fluoren-9-yl)methoxy)carbonyl)(2,4-dimethoxybenzyl)amino)acetic acid (166881-42-1)

Guidance literature:

In 1,4-dioxane; for 0.5h;

DOI:10.1039/c3ob42238k

upstream raw materials:

(2,4-dimethoxy-benzylamino)-acetic acid

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

2,4-Dimethoxybenzaldehyde

Downstream raw materials:

Ac-Asn(β-GlcNAc)-Gly-Ala-Tyr-Ser-OH

bivalirudin

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