N-((S)-2-amino-3-((S)-1-((S)-3-cyclohexyl-1-((2S,3R)-3-hydroxy-4-oxo-1-phenyl-4-(1-phenylcyclopentylamino)butan-2-ylamino)-1-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-oxopropyl)-5-fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamide

Base Information

Chemical Name:N-((S)-2-amino-3-((S)-1-((S)-3-cyclohexyl-1-((2S,3R)-3-hydroxy-4-oxo-1-phenyl-4-(1-phenylcyclopentylamino)butan-2-ylamino)-1-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-oxopropyl)-5-fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamide
CAS No.:1333494-88-4
Molecular Formula:C₄₃H₅₇FN₈O₈
Molecular Weight:832.973
Hs Code.:

N-((S)-2-amino-3-((S)-1-((S)-3-cyclohexyl-1-((2S,3R)-3-hydroxy-4-oxo-1-phenyl-4-(1-phenylcyclopentylamino)butan-2-ylamino)-1-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-oxopropyl)-5-fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamide

Synonyms:N-((S)-2-amino-3-((S)-1-((S)-3-cyclohexyl-1-((2S,3R)-3-hydroxy-4-oxo-1-phenyl-4-(1-phenylcyclopentylamino)butan-2-ylamino)-1-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-oxopropyl)-5-fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamide

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Chemical Property of N-((S)-2-amino-3-((S)-1-((S)-3-cyclohexyl-1-((2S,3R)-3-hydroxy-4-oxo-1-phenyl-4-(1-phenylcyclopentylamino)butan-2-ylamino)-1-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-oxopropyl)-5-fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamide

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Technology Process of N-((S)-2-amino-3-((S)-1-((S)-3-cyclohexyl-1-((2S,3R)-3-hydroxy-4-oxo-1-phenyl-4-(1-phenylcyclopentylamino)butan-2-ylamino)-1-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-oxopropyl)-5-fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamide

There total 14 articles about N-((S)-2-amino-3-((S)-1-((S)-3-cyclohexyl-1-((2S,3R)-3-hydroxy-4-oxo-1-phenyl-4-(1-phenylcyclopentylamino)butan-2-ylamino)-1-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-oxopropyl)-5-fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₈H₆₅FN₈O₁₀

: 1333494-88-4
N-((S)-2-amino-3-((S)-1-((S)-3-cyclohexyl-1-((2S,3R)-3-hydroxy-4-oxo-1-phenyl-4-(1-phenylcyclopentylamino)butan-2-ylamino)-1-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-oxopropyl)-5-fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 0 - 20 ℃; for 1h;
DOI:10.1016/j.bmc.2011.07.002

Reference yield:

: C₂₆H₃₄N₂O₄

: 1333494-88-4
N-((S)-2-amino-3-((S)-1-((S)-3-cyclohexyl-1-((2S,3R)-3-hydroxy-4-oxo-1-phenyl-4-(1-phenylcyclopentylamino)butan-2-ylamino)-1-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-oxopropyl)-5-fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1: hydrogenchloride / 1,4-dioxane / 1 h / 0 - 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 1 h / 0 - 20 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C

5: hydrogenchloride / 1,4-dioxane / 1 h / 0 - 20 °C

6: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C

7: diethylamine / N,N-dimethyl-formamide / 20 °C

8: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C

9: hydrogenchloride / 1,4-dioxane / 1 h / 0 - 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.07.002

Reference yield:

: C₂₁H₂₆N₂O₂

: 1333494-88-4
N-((S)-2-amino-3-((S)-1-((S)-3-cyclohexyl-1-((2S,3R)-3-hydroxy-4-oxo-1-phenyl-4-(1-phenylcyclopentylamino)butan-2-ylamino)-1-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-oxopropyl)-5-fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 1 h / 0 - 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C

4: hydrogenchloride / 1,4-dioxane / 1 h / 0 - 20 °C

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C

6: diethylamine / N,N-dimethyl-formamide / 20 °C

7: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C

8: hydrogenchloride / 1,4-dioxane / 1 h / 0 - 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.07.002