4-(3-((tert-butyldimethylsilyl)oxy)cyclohexa-1,3-dien-1-yl)-3-nitropyridine

Base Information

• Chemical Name: 4-(3-((tert-butyldimethylsilyl)oxy)cyclohexa-1,3-dien-1-yl)-3-nitropyridine
• CAS No.: 1405128-65-5
• Molecular Formula: C₁₇H₂₄N₂O₃Si
• Molecular Weight: 332.475
• Mol file: 1405128-65-5.mol

Synonyms:4-(3-((tert-butyldimethylsilyl)oxy)cyclohexa-1,3-dien-1-yl)-3-nitropyridine

Chemical Property of 4-(3-((tert-butyldimethylsilyl)oxy)cyclohexa-1,3-dien-1-yl)-3-nitropyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 4-(3-((tert-butyldimethylsilyl)oxy)cyclohexa-1,3-dien-1-yl)-3-nitropyridine

There total 1 articles about 4-(3-((tert-butyldimethylsilyl)oxy)cyclohexa-1,3-dien-1-yl)-3-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3-(3-nitropyridin-4-yl)cyclohex-2-en-1-one (1187055-82-8) + t-butyldimethylsiyl triflate (69739-34-0) → 4-(3-((tert-butyldimethylsilyl)oxy)cyclohexa-1,3-dien-1-yl)-3-nitropyridine (1405128-65-5)

Guidance literature:

3-(3-nitropyridin-4-yl)cyclohex-2-en-1-one; t-butyldimethylsiyl triflate; With triethylamine; In chloroform; at -5 ℃; Inert atmosphere;

With 2-Hydroxymethylpyridine; In chloroform; for 0.5h; Cooling with ice; Inert atmosphere;

Reference yield: 89.0%

4-(3-((tert-butyldimethylsilyl)oxy)cyclohexa-1,3-dien-1-yl)-3-nitropyridine (1405128-65-5) → 6-fluoro-3-(3-nitropyridin-4-yl)cyclohex-2-enone (1405128-66-6)

Guidance literature:

With Selectfluor; In acetonitrile; at 5 ℃; for 17h; Inert atmosphere;

Reference yield:

4-(3-((tert-butyldimethylsilyl)oxy)cyclohexa-1,3-dien-1-yl)-3-nitropyridine (1405128-65-5) → 6-fluoro-3-(3-nitropyridin-4-yl)cyclohex-2-enol (1405128-67-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Selectfluor / acetonitrile / 17 h / 5 °C / Inert atmosphere

2: ethanol; sodium tetrahydroborate; cerium (III) chloride pentahydrate / 20 - 45 °C / Inert atmosphere

With sodium tetrahydroborate; ethanol; cerium (III) chloride pentahydrate; Selectfluor; In acetonitrile;

upstream raw materials:

3-(3-nitropyridin-4-yl)cyclohex-2-en-1-one

t-butyldimethylsiyl triflate

Downstream raw materials:

6-fluoro-3-(3-nitropyridin-4-yl)cyclohex-2-enone

6-fluoro-3-(3-nitropyridin-4-yl)cyclohex-2-enol