Phosphoric acid benzyl ester (R)-3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl ester (S)-2-(4-methoxy-benzyloxy)-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-propyl ester

Base Information

• Chemical Name: Phosphoric acid benzyl ester (R)-3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl ester (S)-2-(4-methoxy-benzyloxy)-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-propyl ester
• CAS No.: 912845-80-8
• Molecular Formula: C₆₅H₇₁O₁₁PSi
• Molecular Weight: 1087.33

Synonyms:Phosphoric acid benzyl ester (R)-3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl ester (S)-2-(4-methoxy-benzyloxy)-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-propyl ester

Chemical Property of Phosphoric acid benzyl ester (R)-3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl ester (S)-2-(4-methoxy-benzyloxy)-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-propyl ester

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Technology Process of Phosphoric acid benzyl ester (R)-3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl ester (S)-2-(4-methoxy-benzyloxy)-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-propyl ester

There total 5 articles about Phosphoric acid benzyl ester (R)-3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl ester (S)-2-(4-methoxy-benzyloxy)-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Phosphorous acid benzyl ester (R)-3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl ester (S)-2-(4-methoxy-benzyloxy)-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-propyl ester → Phosphoric acid benzyl ester (R)-3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl ester (S)-2-(4-methoxy-benzyloxy)-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-propyl ester (912845-80-8)

Guidance literature:

With tert.-butylhydroperoxide; In decane; dichloromethane; at 20 ℃;

DOI:10.1016/j.bmc.2006.05.055

Reference yield:

2-O-(4-methoxybenzyl)-1-O-(tert-butyldiphenylsilyl)-sn-glycerol (544686-85-3) → Phosphoric acid benzyl ester (R)-3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl ester (S)-2-(4-methoxy-benzyloxy)-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-propyl ester (912845-80-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 98 percent / pyridine / CH₂Cl₂ / 20 °C

2: 96 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 20 °C

3: tetrazole / CH₂Cl₂ / 1.5 h / 20 °C

4: 7.89 g / tert-butylhydroperoxide / CH₂Cl₂; decane / 20 °C

With pyridine; 1H-tetrazole; tert.-butylhydroperoxide; tetrabutyl ammonium fluoride; In tetrahydrofuran; decane; dichloromethane;

DOI:10.1016/j.bmc.2006.05.055

Reference yield:

2-O-(4-methoxybenzyl)-3-O-monomethoxytrityl-sn-glycerol (912845-79-5) → Phosphoric acid benzyl ester (R)-3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl ester (S)-2-(4-methoxy-benzyloxy)-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-propyl ester (912845-80-8)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrazole / CH₂Cl₂ / 1.5 h / 20 °C

2: 7.89 g / tert-butylhydroperoxide / CH₂Cl₂; decane / 20 °C

With 1H-tetrazole; tert.-butylhydroperoxide; In decane; dichloromethane;

DOI:10.1016/j.bmc.2006.05.055

upstream raw materials:

2-O-(4-methoxybenzyl)-1-O-(tert-butyldiphenylsilyl)-sn-glycerol

2-O-(4-methoxybenzyl)-3-O-monomethoxytrityl-sn-glycerol

1-O-(tert-butyldiphenylsilyl)-2-O-(4-methoxybenzyl)-3-O-(4-monomethoxytrityl)-sn-glycerol

mono-4-methoxytrityl chloride

Downstream raw materials:

3-O-[2-O-(4-methoxybenzyl)-3-O-(4-monomethoxytrityl)-sn-glycero-⁽¹⁾-(benzyl)phospho]-2-O-(4-methoxybenzyl)-sn-glycerol

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