Technology Process of ethyl 3-(5-((1S,2R)-7-(benzyloxy)-1,2-dihydroxyheptyl)furan-2-yl)propanoate
There total 1 articles about ethyl 3-(5-((1S,2R)-7-(benzyloxy)-1,2-dihydroxyheptyl)furan-2-yl)propanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium osmate(VI) dihydrate; methanesulfonamide; potassium carbonate; 1,4-bis(9-O-dihydroquinidine)phthalazine;
In
water; tert-butyl alcohol;
at 0 ℃;
for 96h;
Overall yield = 84 %; Overall yield = 9.16 g; enantioselective reaction;
DOI:10.1021/jo501142q
- Guidance literature:
-
ethyl 3-(5-((1S,2R)-7-(benzyloxy)-1,2-dihydroxyheptyl)furan-2-yl)propanoate;
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
at 0 ℃;
for 2h;
With
camphor-10-sulfonic acid;
In
dichloromethane;
at 0 ℃;
for 0.333333h;
DOI:10.1021/jo501142q
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 °C
1.2: 0.33 h / 0 °C
2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2.17 h / 20 °C / 760.05 Torr / Inert atmosphere
3.1: potassium tri-sec-butyl-borohydride / tetrahydrofuran; toluene / 2 h / -78 °C
4.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C
With
1H-imidazole; palladium 10% on activated carbon; hydrogen; potassium tri-sec-butyl-borohydride; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo501142q
