N'-(9-{4-azido-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethyl-formamidine

Base Information

Chemical Name:N'-(9-{4-azido-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethyl-formamidine
CAS No.:719288-83-2
Molecular Formula:C₃₄H₃₅N₉O₅
Molecular Weight:649.709
Hs Code.:

<i>N</i>'-(9-{4-azido-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1<i>H</i>-purin-2-yl)-<i>N</i>,<i>N</i>-dimethyl-formamidine

Synonyms:N'-(9-{4-azido-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethyl-formamidine

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Chemical Property of N'-(9-{4-azido-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethyl-formamidine

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Technology Process of N'-(9-{4-azido-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethyl-formamidine

There total 11 articles about N'-(9-{4-azido-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethyl-formamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 719288-82-1
Methanesulfonic acid (2R,3R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[2-(dimethylamino-methyleneamino)-6-oxo-1,6-dihydro-purin-9-yl]-tetrahydro-furan-3-yl ester

: 719288-83-2
N'-(9-{4-azido-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethyl-formamidine

Guidance literature:: With lithium azide; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1081/NCN-120027826

Reference yield:

: 719288-74-1
N²-isobutyryl-2'-O-methanesulfonylguanosine

: 719288-83-2
N'-(9-{4-azido-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethyl-formamidine

Guidance literature:: Multi-step reaction with 6 steps

1: 79 percent / pyridine / 3 h

2: 96 percent / NH₃ / methanol / 20 °C

3: 90 percent / L-Selectride(R) / tetrahydrofuran / 3.5 h / cooling

4: pyridine / 20 °C

5: 2.6 g / DMAP; pyridine / 20 h

6: 75 percent / LiN₃ / dimethylformamide / 3 h / 20 °C

With pyridine; dmap; lithium azide; ammonia; L-Selectride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1081/NCN-120027826

Reference yield:

: 5'-O-dimethoxytrityl-N₂-dimethylaminomethylidene-xylo-2'-deoxyguanosine

: 719288-83-2
N'-(9-{4-azido-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethyl-formamidine

Guidance literature:: Multi-step reaction with 2 steps

1: 2.6 g / DMAP; pyridine / 20 h

2: 75 percent / LiN₃ / dimethylformamide / 3 h / 20 °C

With pyridine; dmap; lithium azide; In N,N-dimethyl-formamide;
DOI:10.1081/NCN-120027826