(4S,5R)-3-((1S,2S)-2-Benzyloxymethyl-2-ethoxy-4-oxo-cyclopentyl)-4,5-diphenyl-oxazolidin-2-one

Base Information

Chemical Name:(4S,5R)-3-((1S,2S)-2-Benzyloxymethyl-2-ethoxy-4-oxo-cyclopentyl)-4,5-diphenyl-oxazolidin-2-one
CAS No.:267411-98-3
Molecular Formula:C₃₀H₃₁NO₅
Molecular Weight:485.58
Hs Code.:

Synonyms:(4S,5R)-3-((1S,2S)-2-Benzyloxymethyl-2-ethoxy-4-oxo-cyclopentyl)-4,5-diphenyl-oxazolidin-2-one

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Chemical Property of (4S,5R)-3-((1S,2S)-2-Benzyloxymethyl-2-ethoxy-4-oxo-cyclopentyl)-4,5-diphenyl-oxazolidin-2-one

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Technology Process of (4S,5R)-3-((1S,2S)-2-Benzyloxymethyl-2-ethoxy-4-oxo-cyclopentyl)-4,5-diphenyl-oxazolidin-2-one

There total 1 articles about (4S,5R)-3-((1S,2S)-2-Benzyloxymethyl-2-ethoxy-4-oxo-cyclopentyl)-4,5-diphenyl-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1774-47-6
trimethylsulfoxonium iodide

: (4S,5R)-3-((1S,2S)-2-Benzyloxymethyl-2-ethoxy-3-oxo-cyclobutyl)-4,5-diphenyl-oxazolidin-2-one

: 267411-95-0
(4S,5R)-3-((S)-2-Benzyloxymethyl-4-oxo-cyclopent-2-enyl)-4,5-diphenyl-oxazolidin-2-one

: 267411-98-3
(4S,5R)-3-((1S,2S)-2-Benzyloxymethyl-2-ethoxy-4-oxo-cyclopentyl)-4,5-diphenyl-oxazolidin-2-one

Guidance literature:: With sodium hydride; scandium tris(trifluoromethanesulfonate); In N,N-dimethyl-formamide; at 50 ℃; for 5h;
DOI:10.1021/jo9919759

Reference yield: 96.0%

: 267411-98-3
(4S,5R)-3-((1S,2S)-2-Benzyloxymethyl-2-ethoxy-4-oxo-cyclopentyl)-4,5-diphenyl-oxazolidin-2-one

: 267411-95-0
(4S,5R)-3-((S)-2-Benzyloxymethyl-4-oxo-cyclopent-2-enyl)-4,5-diphenyl-oxazolidin-2-one

Guidance literature:: With lithium carbonate; In methanol; for 2.5h;
DOI:10.1021/jo9919759

Reference yield:

: 267411-98-3
(4S,5R)-3-((1S,2S)-2-Benzyloxymethyl-2-ethoxy-4-oxo-cyclopentyl)-4,5-diphenyl-oxazolidin-2-one

: 7-((1S,4R)-4-Benzyloxymethyl-cyclopent-2-enyl)-6-chloro-7H-purin-2-ylamine

Guidance literature:: Multi-step reaction with 6 steps

1: 96 percent / Li₂CO₃ / methanol / 2.5 h

2: 77 percent / H₂ / [Rh(COD)dppb]BF₄ / dimethylformamide / 18.5 h / 4137.29 Torr

3: LDA / tetrahydrofuran; hexane / 0.25 h / 0 °C

4: 55.4 mg / DIBAL / tetrahydrofuran / -78 - 0 °C

5: 87 percent / pyridine / CH₂Cl₂ / 0.33 h

6: 20 percent / Pd(PPh₃)4 / dimethylformamide / 3.5 h / -40 - 10 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; lithium carbonate; diisobutylaluminium hydride; lithium diisopropyl amide; [Rh(COD)(DPPB)]BF₄; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; 1: Elimination / 2: Catalytic hydrogenation / 3: Elimination / 4: Reduction / 5: Condensation / 6: Substitution;
DOI:10.1021/jo9919759