8-(4-(diethoxymethyl)phenyl)-9-(1-methyl-1H-imidazol-2-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

Base Information

Chemical Name:8-(4-(diethoxymethyl)phenyl)-9-(1-methyl-1H-imidazol-2-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one
CAS No.:1207453-99-3
Molecular Formula:C₂₅H₂₇N₅O₃
Molecular Weight:445.521
Hs Code.:

Synonyms:8-(4-(diethoxymethyl)phenyl)-9-(1-methyl-1H-imidazol-2-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

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Chemical Property of 8-(4-(diethoxymethyl)phenyl)-9-(1-methyl-1H-imidazol-2-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

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Technology Process of 8-(4-(diethoxymethyl)phenyl)-9-(1-methyl-1H-imidazol-2-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

There total 8 articles about 8-(4-(diethoxymethyl)phenyl)-9-(1-methyl-1H-imidazol-2-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1207453-98-2
ethyl 2-(4-(diethoxymethyl)phenyl)-3-(1-methyl-1H-imidazol-2-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate

: 1207453-99-3
8-(4-(diethoxymethyl)phenyl)-9-(1-methyl-1H-imidazol-2-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

Guidance literature:: With hydrazine hydrate; In methanol; at 25 ℃; for 3h;

Reference yield:

: 697739-03-0
5-fluoro-2-methyl-3-nitrobenzoic acid methyl ester

: 1207453-99-3
8-(4-(diethoxymethyl)phenyl)-9-(1-methyl-1H-imidazol-2-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / Reflux

2: 1,4-dioxane; water / 96 h / Reflux

3: hydrogen / palladium 10% on activated carbon / ethyl acetate / 12 h / 25 °C / 760.05 Torr

4: magnesium sulfate / dichloromethane / Reflux

5: ethanol / 3 h / 20 °C

6: hydrazine hydrate / methanol / 3 h / 25 °C

With N-Bromosuccinimide; hydrogen; magnesium sulfate; hydrazine hydrate; dibenzoyl peroxide; palladium 10% on activated carbon; In 1,4-dioxane; methanol; tetrachloromethane; ethanol; dichloromethane; water; ethyl acetate;

Reference yield:

: 33184-16-6
5-fluoro-2-methylbenzoic acid

: 1207453-99-3
8-(4-(diethoxymethyl)phenyl)-9-(1-methyl-1H-imidazol-2-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

Guidance literature:: Multi-step reaction with 8 steps

1: nitric acid / sulfuric acid / 3.5 h / -5 - 0 °C

2: thionyl chloride / methanol / 16 h / 0 °C / Reflux

3: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / Reflux

4: 1,4-dioxane; water / 96 h / Reflux

5: hydrogen / palladium 10% on activated carbon / ethyl acetate / 12 h / 25 °C / 760.05 Torr

6: magnesium sulfate / dichloromethane / Reflux

7: ethanol / 3 h / 20 °C

8: hydrazine hydrate / methanol / 3 h / 25 °C

With N-Bromosuccinimide; thionyl chloride; hydrogen; nitric acid; magnesium sulfate; hydrazine hydrate; dibenzoyl peroxide; sulfuric acid; palladium 10% on activated carbon; In 1,4-dioxane; methanol; tetrachloromethane; ethanol; dichloromethane; water; ethyl acetate;