{[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(2-{[2-(6-tert-butoxycarbonylamino-hexanoylamino)-ethyl]-[(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-ethyl]-amino}-acetic acid

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Chemical Name:{[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(2-{[2-(6-tert-butoxycarbonylamino-hexanoylamino)-ethyl]-[(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-ethyl]-amino}-acetic acid
CAS No.:221555-29-9
Molecular Formula:C₃₉H₅₂N₁₀O₁₃
Molecular Weight:868.901
Hs Code.:

{[(4-benzyloxycarbonylamino-2-oxo-2<i>H</i>-pyrimidin-1-yl)-acetyl]-[2-(2-{[2-(6-<i>tert</i>-butoxycarbonylamino-hexanoylamino)-ethyl]-[(2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-ethyl]-amino}-acetic acid

Synonyms:{[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(2-{[2-(6-tert-butoxycarbonylamino-hexanoylamino)-ethyl]-[(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-ethyl]-amino}-acetic acid

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Chemical Property of {[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(2-{[2-(6-tert-butoxycarbonylamino-hexanoylamino)-ethyl]-[(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-ethyl]-amino}-acetic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of {[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(2-{[2-(6-tert-butoxycarbonylamino-hexanoylamino)-ethyl]-[(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-ethyl]-amino}-acetic acid

There total 7 articles about {[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(2-{[2-(6-tert-butoxycarbonylamino-hexanoylamino)-ethyl]-[(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-ethyl]-amino}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 221555-26-6
{[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(2-{[2-(6-tert-butoxycarbonylamino-hexanoylamino)-ethyl]-[(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-ethyl]-amino}-acetic acid methyl ester

: 221555-29-9
{[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(2-{[2-(6-tert-butoxycarbonylamino-hexanoylamino)-ethyl]-[(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-ethyl]-amino}-acetic acid

Guidance literature:: With lithium hydroxide; In 1,4-dioxane; at 0 ℃; for 1h;
DOI:10.1016/S0040-4020(98)01211-3

Reference yield:

: 6404-29-1
6-(tert-butoxycarbonylamino)hexanoic acid

: 221555-29-9
{[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(2-{[2-(6-tert-butoxycarbonylamino-hexanoylamino)-ethyl]-[(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-ethyl]-amino}-acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) HOSu, DCC, 2.) NMM / 1.) DMF, room temperature, 12 h, 2.) DMF, -15 deg C (3 h), -> room temperature (2 h)

2: 80 percent / TEA, Brop / CH₂Cl₂ / 2 h / Ambient temperature

3: 100 percent / aq. LiOH / dioxane / 1 h / 0 °C

4: 60 percent / NMM, Bop / dimethylformamide / 1.) -15 deg C, 3 h, 2.) room temperature, 2 h

5: 70 percent / Et₃N, Brop / CH₂Cl₂ / 2 h / Ambient temperature

6: 75 percent / aq. LiOH / dioxane / 1 h / 0 °C

With 4-methyl-morpholine; lithium hydroxide; 1-hydroxy-pyrrolidine-2,5-dione; bromo-tris-dimethylamino-phosphonium hexafluorophosphate; TEA; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(98)01211-3

Reference yield:

: 4113-97-7
uracilacetic acid

: 221555-29-9
{[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(2-{[2-(6-tert-butoxycarbonylamino-hexanoylamino)-ethyl]-[(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-ethyl]-amino}-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / TEA, Brop / CH₂Cl₂ / 2 h / Ambient temperature

2: 100 percent / aq. LiOH / dioxane / 1 h / 0 °C

3: 60 percent / NMM, Bop / dimethylformamide / 1.) -15 deg C, 3 h, 2.) room temperature, 2 h

4: 70 percent / Et₃N, Brop / CH₂Cl₂ / 2 h / Ambient temperature

5: 75 percent / aq. LiOH / dioxane / 1 h / 0 °C

With 4-methyl-morpholine; lithium hydroxide; bromo-tris-dimethylamino-phosphonium hexafluorophosphate; TEA; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(98)01211-3