2-[5-(3-{5-[2-benzyloxy-3-(5-methyl-tetrahydro-furan-2-yl)-butyl]-tetrahydro-furan-2-yl}-2-oxo-butyl)-tetrahydro-furan-2-yl]-propionic acid

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Chemical Name:2-[5-(3-{5-[2-benzyloxy-3-(5-methyl-tetrahydro-furan-2-yl)-butyl]-tetrahydro-furan-2-yl}-2-oxo-butyl)-tetrahydro-furan-2-yl]-propionic acid
CAS No.:919608-22-3
Molecular Formula:C₃₁H₄₆O₇
Molecular Weight:530.702
Hs Code.:

Synonyms:2-[5-(3-{5-[2-benzyloxy-3-(5-methyl-tetrahydro-furan-2-yl)-butyl]-tetrahydro-furan-2-yl}-2-oxo-butyl)-tetrahydro-furan-2-yl]-propionic acid

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Chemical Property of 2-[5-(3-{5-[2-benzyloxy-3-(5-methyl-tetrahydro-furan-2-yl)-butyl]-tetrahydro-furan-2-yl}-2-oxo-butyl)-tetrahydro-furan-2-yl]-propionic acid

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Technology Process of 2-[5-(3-{5-[2-benzyloxy-3-(5-methyl-tetrahydro-furan-2-yl)-butyl]-tetrahydro-furan-2-yl}-2-oxo-butyl)-tetrahydro-furan-2-yl]-propionic acid

There total 28 articles about 2-[5-(3-{5-[2-benzyloxy-3-(5-methyl-tetrahydro-furan-2-yl)-butyl]-tetrahydro-furan-2-yl}-2-oxo-butyl)-tetrahydro-furan-2-yl]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 919608-13-2
{5-[2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-tetrahydro-furan-2-yl}-methanol

: 919608-22-3
2-[5-(3-{5-[2-benzyloxy-3-(5-methyl-tetrahydro-furan-2-yl)-butyl]-tetrahydro-furan-2-yl}-2-oxo-butyl)-tetrahydro-furan-2-yl]-propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 89 percent / SO₃*pyridine; TEA; DMSO / CH₂Cl₂ / 0.5 h / 20 °C

2.1: 557 mg / tetrahydrofuran; hexane / -78 - 20 °C

3.1: 85 percent / m-CPBA / CH₂Cl₂ / 3 h

4.1: lithium aluminum hydride / diethyl ether / 12 h

4.2: 30 mg / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

5.1: 99 percent / NaClO₂; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 2 h / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; lithium aluminium tetrahydride; 2-methyl-but-2-ene; pyridine-SO₃ complex; TEA; dimethyl sulfoxide; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; tert-butyl alcohol; 2.1: Wittig olefination / 4.2: Dess-Martin oxidation;
DOI:10.1016/j.tet.2007.07.005

Reference yield:

: 919608-28-9
3-[5-(2,2-dimethyl-[1,3]dioxolan-4-yl)-3-hydroxy-2-methyl-pentanoyl]-4-methyl-5-phenyl-oxazolidin-2-one

: 919608-22-3
2-[5-(3-{5-[2-benzyloxy-3-(5-methyl-tetrahydro-furan-2-yl)-butyl]-tetrahydro-furan-2-yl}-2-oxo-butyl)-tetrahydro-furan-2-yl]-propionic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: lithium borohydride / diethyl ether; tetrahydrofuran / 0 - 20 °C

2.1: 3.59 g / imidazole / CH₂Cl₂ / 1 h / 20 °C

3.1: 98 percent / TEA / CH₂Cl₂ / 0 - 20 °C

4.1: 84 percent / CSA; methanol / 2 h / 20 °C

5.1: 80 percent / sodium hexamethyldisilazide / tetrahydrofuran / 0 - 20 °C

6.1: 89 percent / SO₃*pyridine; TEA; DMSO / CH₂Cl₂ / 0.5 h / 20 °C

7.1: 557 mg / tetrahydrofuran; hexane / -78 - 20 °C

8.1: 85 percent / m-CPBA / CH₂Cl₂ / 3 h

9.1: lithium aluminum hydride / diethyl ether / 12 h

9.2: 30 mg / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

10.1: 99 percent / NaClO₂; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 2 h / 20 °C

With 1H-imidazole; methanol; sodium chlorite; sodium dihydrogenphosphate; lithium aluminium tetrahydride; lithium borohydride; 2-methyl-but-2-ene; pyridine-SO₃ complex; TEA; camphor-10-sulfonic acid; sodium hexamethyldisilazane; dimethyl sulfoxide; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; tert-butyl alcohol; 5.1: Williamson ether synthesis / 7.1: Wittig olefination / 9.2: Dess-Martin oxidation;
DOI:10.1016/j.tet.2007.07.005

Reference yield:

: 919608-12-1
1-(tert-butyl-diphenyl-silanyloxy)-5-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-pentan-3-ol

: 919608-22-3
2-[5-(3-{5-[2-benzyloxy-3-(5-methyl-tetrahydro-furan-2-yl)-butyl]-tetrahydro-furan-2-yl}-2-oxo-butyl)-tetrahydro-furan-2-yl]-propionic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: 98 percent / TEA / CH₂Cl₂ / 0 - 20 °C

2.1: 84 percent / CSA; methanol / 2 h / 20 °C

3.1: 80 percent / sodium hexamethyldisilazide / tetrahydrofuran / 0 - 20 °C

4.1: 89 percent / SO₃*pyridine; TEA; DMSO / CH₂Cl₂ / 0.5 h / 20 °C

5.1: 557 mg / tetrahydrofuran; hexane / -78 - 20 °C

6.1: 85 percent / m-CPBA / CH₂Cl₂ / 3 h

7.1: lithium aluminum hydride / diethyl ether / 12 h

7.2: 30 mg / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

8.1: 99 percent / NaClO₂; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 2 h / 20 °C

With methanol; sodium chlorite; sodium dihydrogenphosphate; lithium aluminium tetrahydride; 2-methyl-but-2-ene; pyridine-SO₃ complex; TEA; camphor-10-sulfonic acid; sodium hexamethyldisilazane; dimethyl sulfoxide; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; tert-butyl alcohol; 3.1: Williamson ether synthesis / 5.1: Wittig olefination / 7.2: Dess-Martin oxidation;
DOI:10.1016/j.tet.2007.07.005