3,5-Dichloropyridazine

Base Information

• Chemical Name: 3,5-Dichloropyridazine
• CAS No.: 1837-55-4
• Molecular Formula: C4H2Cl2N2
• Molecular Weight: 148.979
• Hs Code.: 29339900
• Mol file: 1837-55-4.mol

Synonyms:3,5-Dichloropyridazine;

Chemical Property of 3,5-Dichloropyridazine

Chemical Property:

• Vapor Pressure: 0.00629mmHg at 25°C
• Melting Point: 60.0 to 64.0 °C
• Refractive Index: 1.559
• Boiling Point: 280.8 °C at 760 mmHg
• PKA: -0.25±0.10(Predicted)
• Flash Point: 150.5 °C
• PSA: 25.78000
• Density: 1.493 g/cm³
• LogP: 1.78340
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: DMSO (Sparingly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

3,5-Dichloropyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,5-Dichloropyridazine used in the treatment of asthma and allergy. Potential for antinociceptive and antiinflammatory effects 3,5-Dichloropyridazine acts as a novel histamine H4 antagonist used in the treatment of asthma and allergy. Potential for antinociceptive and antiinflammatory effects.

Technology Process of 3,5-Dichloropyridazine

There total 4 articles about 3,5-Dichloropyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

5-chloropyridazin-3(2H)-one → 3,5-dichloropyridazine (1837-55-4)

Guidance literature:

With trichlorophosphate; at 80 ℃; for 3h;

Reference yield: 55.0%

(Z)-2,4,4,4-tetrachlorobut-2-enal (1081808-80-1) → 3,5-dichloropyridazine (1837-55-4)

Guidance literature:

With semicarbazide hydrochloride; In water; N,N-dimethyl-formamide; at 15 - 20 ℃; for 49h;

DOI:10.1002/ejoc.201800068

Reference yield:

2,4,4,4-tetrachloro-but-2-enal (19429-51-7) → 3,5-dichloropyridazine (1837-55-4)

Guidance literature:

With semicarbazide hydrochloride; In water; N,N-dimethyl-formamide; at 15 - 20 ℃;

DOI:10.1002/zaac.201900146

upstream raw materials:

(Z)-2,4,4,4-tetrachlorobut-2-enal

2,4,4,4-tetrachloro-but-2-enal

Downstream raw materials:

3,5-dimethoxypyridazine

Refernces

• 1、 Gospodinov, Ivan,Singer, Johannes,Klap?tke, Thomas M.,Stierstorfer, J?rg. "The Pyridazine Scaffold as a Building Block for Energetic Materials: Synthesis, Characterization, and Properties". . p. 1247 - 1254. Retrieved 2019.
• 2、 -. "AMINO-HETEROCYCLES AS VR-1 ANTAGONISTS FOR TREATING PAIN". Page 40. . Retrieved 2010/02/07.