5H-r,7-(p-benzyloxy-o,o'-dimethylphenyl)-cis-3-hydroxy-trans-3-methylheptan-5-olide

Base Information

Chemical Name:5H-r,7-(p-benzyloxy-o,o'-dimethylphenyl)-cis-3-hydroxy-trans-3-methylheptan-5-olide
CAS No.:69172-12-9
Molecular Formula:C₂₃H₂₈O₄
Molecular Weight:368.473
Hs Code.:

Synonyms:5H-r,7-(p-benzyloxy-o,o'-dimethylphenyl)-cis-3-hydroxy-trans-3-methylheptan-5-olide

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Chemical Property of 5H-r,7-(p-benzyloxy-o,o'-dimethylphenyl)-cis-3-hydroxy-trans-3-methylheptan-5-olide

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Technology Process of 5H-r,7-(p-benzyloxy-o,o'-dimethylphenyl)-cis-3-hydroxy-trans-3-methylheptan-5-olide

There total 5 articles about 5H-r,7-(p-benzyloxy-o,o'-dimethylphenyl)-cis-3-hydroxy-trans-3-methylheptan-5-olide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 69172-11-8
(4R,5S,6S)-6-[2-(4-Benzyloxy-2,6-dimethyl-phenyl)-ethyl]-5-bromo-4-hydroxy-4-methyl-tetrahydro-pyran-2-one

: 69172-12-9
5H-r,7-(p-benzyloxy-o,o'-dimethylphenyl)-cis-3-hydroxy-trans-3-methylheptan-5-olide

Guidance literature:: With tri-n-butyl-tin hydride; In tetrahydrofuran; Heating;
DOI:10.1248/cpb.28.1509

Reference yield:

: 60995-71-3
3-(p-benzyloxy-o,o'-dimethylphenyl)propionaldehyde

: 69172-12-9
5H-r,7-(p-benzyloxy-o,o'-dimethylphenyl)-cis-3-hydroxy-trans-3-methylheptan-5-olide

Guidance literature:: Multi-step reaction with 5 steps

1: 50percent NaH / tetrahydrofuran / 2 h / -20 °C

2: 71.2 percent / Zn / benzene / 1 h / Heating

3: aq. NaOH / methanol

4: NaHCO₃, Br₂ / methanol / 1 h / -70 °C

5: 79 percent / tri-n-butyltin hydride / tetrahydrofuran / Heating

With sodium hydroxide; bromine; tri-n-butyl-tin hydride; sodium hydride; sodium hydrogencarbonate; zinc; In tetrahydrofuran; methanol; benzene;
DOI:10.1248/cpb.28.1509

Reference yield:

: 69171-89-7
6-(p-benzyloxy-o,o'-dimethylphenyl)-trans-3-hexen-2-one

: 69172-12-9
5H-r,7-(p-benzyloxy-o,o'-dimethylphenyl)-cis-3-hydroxy-trans-3-methylheptan-5-olide

Guidance literature:: Multi-step reaction with 4 steps

1: 71.2 percent / Zn / benzene / 1 h / Heating

2: aq. NaOH / methanol

3: NaHCO₃, Br₂ / methanol / 1 h / -70 °C

4: 79 percent / tri-n-butyltin hydride / tetrahydrofuran / Heating

With sodium hydroxide; bromine; tri-n-butyl-tin hydride; sodium hydrogencarbonate; zinc; In tetrahydrofuran; methanol; benzene;
DOI:10.1248/cpb.28.1509