(2S,4S,5S)-5-amino-6-(3-(1-(t-butoxycarbonylamino)ethyl)benzyloxy)-4-hydroxy-2-isopropyl-hexanoic acid ((S)-1-benzylcarbamoyl-2-methyl-propyl)-amide

Base Information

Chemical Name:(2S,4S,5S)-5-amino-6-(3-(1-(t-butoxycarbonylamino)ethyl)benzyloxy)-4-hydroxy-2-isopropyl-hexanoic acid ((S)-1-benzylcarbamoyl-2-methyl-propyl)-amide
CAS No.:1056671-27-2
Molecular Formula:C₃₅H₅₄N₄O₆
Molecular Weight:626.837
Hs Code.:

(2S,4S,5S)-5-amino-6-(3-(1-(t-butoxycarbonylamino)ethyl)benzyloxy)-4-hydroxy-2-isopropyl-hexanoic acid ((S)-1-benzylcarbamoyl-2-methyl-propyl)-amide

Synonyms:(2S,4S,5S)-5-amino-6-(3-(1-(t-butoxycarbonylamino)ethyl)benzyloxy)-4-hydroxy-2-isopropyl-hexanoic acid ((S)-1-benzylcarbamoyl-2-methyl-propyl)-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4S,5S)-5-amino-6-(3-(1-(t-butoxycarbonylamino)ethyl)benzyloxy)-4-hydroxy-2-isopropyl-hexanoic acid ((S)-1-benzylcarbamoyl-2-methyl-propyl)-amide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2S,4S,5S)-5-amino-6-(3-(1-(t-butoxycarbonylamino)ethyl)benzyloxy)-4-hydroxy-2-isopropyl-hexanoic acid ((S)-1-benzylcarbamoyl-2-methyl-propyl)-amide

There total 19 articles about (2S,4S,5S)-5-amino-6-(3-(1-(t-butoxycarbonylamino)ethyl)benzyloxy)-4-hydroxy-2-isopropyl-hexanoic acid ((S)-1-benzylcarbamoyl-2-methyl-propyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1056675-55-8
(2S,4S,5S)-5-azido-6-(3-((1RS)-1-(t-butoxycarbonylamino)ethyl)benzyloxy)-4-hydroxy-2-isopropyl-hexanoic acid ((S)-1-benzylcarbamoyl-2-methyl-propyl)-amide

: 1056671-27-2
(2S,4S,5S)-5-amino-6-(3-(1-(t-butoxycarbonylamino)ethyl)benzyloxy)-4-hydroxy-2-isopropyl-hexanoic acid ((S)-1-benzylcarbamoyl-2-methyl-propyl)-amide

Guidance literature:: With Lindlar's catalyst; hydrogen; In ethanol; at 20 ℃; under 760.051 Torr;
DOI:10.1016/j.bmcl.2010.10.140

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 1056671-27-2
(2S,4S,5S)-5-amino-6-(3-(1-(t-butoxycarbonylamino)ethyl)benzyloxy)-4-hydroxy-2-isopropyl-hexanoic acid ((S)-1-benzylcarbamoyl-2-methyl-propyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h / 0 °C

1.2: 0.33 h

2.1: trifluoroacetic acid / 1 h / 20 °C

3.1: 2-hydroxypyridin; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 88 h / 70 °C

4.1: hydrogen / Lindlar's catalyst / ethanol / 5 h

With 2-hydroxypyridin; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; Lindlar's catalyst; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1056674-45-3
(3S,5S)-5-((R)-1,2-dihydroxyethyl)-3-isopropyldihydrofuran-2(3H)-one

: 1056671-27-2
(2S,4S,5S)-5-amino-6-(3-(1-(t-butoxycarbonylamino)ethyl)benzyloxy)-4-hydroxy-2-isopropyl-hexanoic acid ((S)-1-benzylcarbamoyl-2-methyl-propyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: di(n-butyl)tin oxide / benzene / 3 h / Heating / reflux

1.2: 80 °C

2.1: pyridine / dichloromethane / 1 h / 0 °C

3.1: sodium azide / N,N-dimethyl-formamide / 1 h / 70 °C

4.1: 2-hydroxypyridin; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 88 h / 70 °C

5.1: hydrogen / Lindlar's catalyst / ethanol / 5 h

With pyridine; 2-hydroxypyridin; sodium azide; hydrogen; di(n-butyl)tin oxide; N-ethyl-N,N-diisopropylamine; Lindlar's catalyst; In ethanol; dichloromethane; N,N-dimethyl-formamide; benzene;