2-(4-(4-(tert-butylcarbamoyl)-2-(((2-chloro-4-cyclopropyl-phenyl)sulfonyl)amino)phenoxy)-5-chloro-2-fluoro-phenyl)acetic acid methyl ester

Base Information

Chemical Name:2-(4-(4-(tert-butylcarbamoyl)-2-(((2-chloro-4-cyclopropyl-phenyl)sulfonyl)amino)phenoxy)-5-chloro-2-fluoro-phenyl)acetic acid methyl ester
CAS No.:1169484-16-5
Molecular Formula:C₂₉H₂₉Cl₂FN₂O₆S
Molecular Weight:623.529
Hs Code.:

Synonyms:2-(4-(4-(tert-butylcarbamoyl)-2-(((2-chloro-4-cyclopropyl-phenyl)sulfonyl)amino)phenoxy)-5-chloro-2-fluoro-phenyl)acetic acid methyl ester

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Chemical Property of 2-(4-(4-(tert-butylcarbamoyl)-2-(((2-chloro-4-cyclopropyl-phenyl)sulfonyl)amino)phenoxy)-5-chloro-2-fluoro-phenyl)acetic acid methyl ester

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Technology Process of 2-(4-(4-(tert-butylcarbamoyl)-2-(((2-chloro-4-cyclopropyl-phenyl)sulfonyl)amino)phenoxy)-5-chloro-2-fluoro-phenyl)acetic acid methyl ester

There total 3 articles about 2-(4-(4-(tert-butylcarbamoyl)-2-(((2-chloro-4-cyclopropyl-phenyl)sulfonyl)amino)phenoxy)-5-chloro-2-fluoro-phenyl)acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 540-88-5
acetic acid tert-butyl ester

: 1169484-12-1
C₂₅H₁₉Cl₂FN₂O₅S

: 1169484-16-5
2-(4-(4-(tert-butylcarbamoyl)-2-(((2-chloro-4-cyclopropyl-phenyl)sulfonyl)amino)phenoxy)-5-chloro-2-fluoro-phenyl)acetic acid methyl ester

Guidance literature:: With methanesulfonic acid; In toluene; at 45 - 50 ℃;

Reference yield:

: 1169483-61-7
2-chloro-4-cyclopropyl-benzene-1-sulfonyl chloride

: 1274666-70-4
C₂₀H₂₂ClFN₂O₄

: 1169484-16-5
2-(4-(4-(tert-butylcarbamoyl)-2-(((2-chloro-4-cyclopropyl-phenyl)sulfonyl)amino)phenoxy)-5-chloro-2-fluoro-phenyl)acetic acid methyl ester

Guidance literature:: With 2,6-dimethylpyridine; In tetrahydrofuran; at 60 ℃; for 12h;
DOI:10.1021/ml1002234

Reference yield:

: 1274666-57-7
C₁₉H₂₀ClFN₂O₄

: 1169484-16-5
2-(4-(4-(tert-butylcarbamoyl)-2-(((2-chloro-4-cyclopropyl-phenyl)sulfonyl)amino)phenoxy)-5-chloro-2-fluoro-phenyl)acetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid / 5 h / 60 °C

2: 2,6-dimethylpyridine / tetrahydrofuran / 12 h / 60 °C

With 2,6-dimethylpyridine; sulfuric acid; In tetrahydrofuran;
DOI:10.1021/ml1002234