3-[5-chloro-2-methyl-4-(3-methyl-benzyloxy)-6-oxo-6H-pyrimidin-1-yl]-N-methoxy-4,N-dimethyl-benzamide

Base Information

• Chemical Name: 3-[5-chloro-2-methyl-4-(3-methyl-benzyloxy)-6-oxo-6H-pyrimidin-1-yl]-N-methoxy-4,N-dimethyl-benzamide
• CAS No.: 1442452-10-9
• Molecular Formula: C₂₃H₂₄ClN₃O₄
• Molecular Weight: 441.914
• Mol file: 1442452-10-9.mol

Synonyms:3-[5-chloro-2-methyl-4-(3-methyl-benzyloxy)-6-oxo-6H-pyrimidin-1-yl]-N-methoxy-4,N-dimethyl-benzamide

Chemical Property of 3-[5-chloro-2-methyl-4-(3-methyl-benzyloxy)-6-oxo-6H-pyrimidin-1-yl]-N-methoxy-4,N-dimethyl-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[5-chloro-2-methyl-4-(3-methyl-benzyloxy)-6-oxo-6H-pyrimidin-1-yl]-N-methoxy-4,N-dimethyl-benzamide

There total 6 articles about 3-[5-chloro-2-methyl-4-(3-methyl-benzyloxy)-6-oxo-6H-pyrimidin-1-yl]-N-methoxy-4,N-dimethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

3-[5-chloro-2-methyl-4-(3-methyl-benzyloxy)-6-oxo-6H-pyrimidin-1-yl]-4-methyl-benzoic acid (1442452-09-6) + N,N-dimethylhydroxylamine hydrochloride (16645-06-0) → 3-[5-chloro-2-methyl-4-(3-methyl-benzyloxy)-6-oxo-6H-pyrimidin-1-yl]-N-methoxy-4,N-dimethyl-benzamide (1442452-10-9)

Guidance literature:

3-[5-chloro-2-methyl-4-(3-methyl-benzyloxy)-6-oxo-6H-pyrimidin-1-yl]-4-methyl-benzoic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 1h;

N,N-dimethylhydroxylamine hydrochloride; With triethylamine; for 18h;

Reference yield:

4-methyl-3-[2-methyl-4-(3-methyl-benzyloxy)-6-oxo-6H-pyrimidin-1-yl]-benzoic acid methyl ester (1442452-07-4) → 3-[5-chloro-2-methyl-4-(3-methyl-benzyloxy)-6-oxo-6H-pyrimidin-1-yl]-N-methoxy-4,N-dimethyl-benzamide (1442452-10-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-chloro-succinimide; dichloro-acetic acid / isopropyl alcohol / 2 h / 60 °C

2.1: sodium hydroxide; water / tetrahydrofuran / 18 h / 20 °C

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 20 °C

3.2: 18 h

With dichloro-acetic acid; N-chloro-succinimide; water; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; isopropyl alcohol;

Reference yield:

3-[5-chloro-2-methyl-4-(3-methyl-benzyloxy)-6-oxo-6H-pyrimidin-1-yl]-4-methyl-benzoic acid methyl ester (1442452-08-5) → 3-[5-chloro-2-methyl-4-(3-methyl-benzyloxy)-6-oxo-6H-pyrimidin-1-yl]-N-methoxy-4,N-dimethyl-benzamide (1442452-10-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / tetrahydrofuran / 18 h / 20 °C

2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 20 °C

2.2: 18 h

With water; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran;

upstream raw materials:

4-methyl-3-[2-methyl-4-(3-methyl-benzyloxy)-6-oxo-6H-pyrimidin-1-yl]-benzoic acid methyl ester

3-[5-chloro-2-methyl-4-(3-methyl-benzyloxy)-6-oxo-6H-pyrimidin-1-yl]-4-methyl-benzoic acid methyl ester

3-(4-hydroxy-2-methyl-6-oxo-6H-pyrimidin-1-yl)-4-methyl-benzoic acid methyl ester

3-[5-chloro-2-methyl-4-(3-methyl-benzyloxy)-6-oxo-6H-pyrimidin-1-yl]-4-methyl-benzoic acid

Downstream raw materials:

5-chloro-2-methyl-6-(3-methyl-benzyloxy)-3-(2-methyl-5-propynoyl-phenyl)-3H-pyrimidin-4-one

3-(5-(2-(tert-butyl)pyrimidin-4-yl)-2-methylphenyl)-5-chloro-2-methyl-6-((3-methylbenzyl)oxy)pyrimidin-4(3H)-one

5-chloro-3-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)-2-methyl-6-((3-methylbenzyl)oxy)pyrimidin-4(3H)-one