Technology Process of ethyl 3-(3,3-difluorocyclobutyl)-3-oxopropanoate
There total 2 articles about ethyl 3-(3,3-difluorocyclobutyl)-3-oxopropanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: diethylamino-sulfur trifluoride / dichloromethane / 0 - 20 °C / Inert atmosphere
2.1: methanesulfonic acid; zinc / tetrahydrofuran / 0.33 h / Inert atmosphere; Reflux
2.2: 2.75 h / Reflux; Inert atmosphere
With
methanesulfonic acid; diethylamino-sulfur trifluoride; zinc;
In
tetrahydrofuran; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: ruthenium trichloride; sodium periodate / water; acetonitrile; dichloromethane / 20 °C / Cooling with ice
2.1: diethylamino-sulfur trifluoride / dichloromethane / 0 - 20 °C / Inert atmosphere
3.1: methanesulfonic acid; zinc / tetrahydrofuran / 0.33 h / Inert atmosphere; Reflux
3.2: 2.75 h / Reflux; Inert atmosphere
With
ruthenium trichloride; sodium periodate; methanesulfonic acid; diethylamino-sulfur trifluoride; zinc;
In
tetrahydrofuran; dichloromethane; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sulfuryl dichloride / dichloromethane / 20 °C / Inert atmosphere
2: ethanol / 6 h / 150 °C / Molecular sieve; Microwave irradiation
3: lithium hydroxide / water; tetrahydrofuran / 20 - 50 °C
With
sulfuryl dichloride; lithium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; water;
